Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell

doi:10.1186/s40348-023-00158-2

Review

. 2023 Apr 18;10(1):4.

doi: 10.1186/s40348-023-00158-2.

Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell

I Mižíková¹, B Thébaud^{2

3

4}

Affiliations

¹ Experimental Pulmonology, Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. ivana.mizikova@uk-koeln.de.
² Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
³ Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
⁴ Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO), CHEO Research Institute, University of Ottawa, Ottawa, ON, Canada.

PMID: 37072570
PMCID: PMC10113423
DOI: 10.1186/s40348-023-00158-2

Review

Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell

I Mižíková et al. Mol Cell Pediatr. 2023.

. 2023 Apr 18;10(1):4.

doi: 10.1186/s40348-023-00158-2.

Authors

I Mižíková¹, B Thébaud^{2

3

4}

Affiliations

¹ Experimental Pulmonology, Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. ivana.mizikova@uk-koeln.de.
² Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
³ Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
⁴ Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO), CHEO Research Institute, University of Ottawa, Ottawa, ON, Canada.

PMID: 37072570
PMCID: PMC10113423
DOI: 10.1186/s40348-023-00158-2

Abstract

Bronchopulmonary dysplasia (BPD) is a multifactorial disease occurring as a consequence of premature birth, as well as antenatal and postnatal injury to the developing lung. BPD morbidity and severity depend on a complex interplay between prenatal and postnatal inflammation, mechanical ventilation, and oxygen therapy as well as associated prematurity-related complications. These initial hits result in ill-explored aberrant immune and reparative response, activation of pro-fibrotic and anti-angiogenic factors, which further perpetuate the injury. Histologically, the disease presents primarily by impaired lung development and an arrest in lung microvascular maturation. Consequently, BPD leads to respiratory complications beyond the neonatal period and may result in premature aging of the lung. While the numerous prenatal and postnatal stimuli contributing to BPD pathogenesis are relatively well known, the specific cell populations driving the injury, as well as underlying mechanisms are still not well understood. Recently, an effort to gain a more detailed insight into the cellular composition of the developing lung and its progenitor populations has unfold. Here, we provide an overview of the current knowledge regarding perinatal origin of BPD and discuss underlying mechanisms, as well as novel approaches to study the perturbed lung development.

Keywords: BPD; Lung development; Prematurity.

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Conflict of interest statement

The authors declare no competing interests.

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References

1. Hilgendorff A, Oâ€TMReilly MA (2015) Bronchopulmonary dysplasia early changes leading to long-term consequences. Front Med. 10.3389/fmed.2015.00002 - PMC - PubMed
1. Thébaud B, Goss KN, Laughon M, et al. Bronchopulmonary dysplasia. Nat Rev Dis Primers. 2019;5:78. doi: 10.1038/s41572-019-0127-7. - DOI - PMC - PubMed
1. Warburton D. Overview of lung development in the newborn human. Neonatology. 2017;111:398–401. doi: 10.1159/000458465. - DOI - PMC - PubMed
1. Duijts L, van Meel ER, Moschino L, et al. European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia. Eur Respir J. 2020;55:1900788. doi: 10.1183/13993003.00788-2019. - DOI - PubMed
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[1] Hilgendorff A, Oâ€TMReilly MA (2015) Bronchopulmonary dysplasia early changes leading to long-term consequences. Front Med. 10.3389/fmed.2015.00002 - PMC - PubMed

[2] Hilgendorff A, Oâ€TMReilly MA (2015) Bronchopulmonary dysplasia early changes leading to long-term consequences. Front Med. 10.3389/fmed.2015.00002 - PMC - PubMed

[3] Thébaud B, Goss KN, Laughon M, et al. Bronchopulmonary dysplasia. Nat Rev Dis Primers. 2019;5:78. doi: 10.1038/s41572-019-0127-7. - DOI - PMC - PubMed

[4] Thébaud B, Goss KN, Laughon M, et al. Bronchopulmonary dysplasia. Nat Rev Dis Primers. 2019;5:78. doi: 10.1038/s41572-019-0127-7. - DOI - PMC - PubMed

[5] Warburton D. Overview of lung development in the newborn human. Neonatology. 2017;111:398–401. doi: 10.1159/000458465. - DOI - PMC - PubMed

[6] Warburton D. Overview of lung development in the newborn human. Neonatology. 2017;111:398–401. doi: 10.1159/000458465. - DOI - PMC - PubMed

[7] Duijts L, van Meel ER, Moschino L, et al. European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia. Eur Respir J. 2020;55:1900788. doi: 10.1183/13993003.00788-2019. - DOI - PubMed

[8] Duijts L, van Meel ER, Moschino L, et al. European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia. Eur Respir J. 2020;55:1900788. doi: 10.1183/13993003.00788-2019. - DOI - PubMed

[9] Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163:1723–1729. doi: 10.1164/ajrccm.163.7.2011060. - DOI - PubMed

[10] Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163:1723–1729. doi: 10.1164/ajrccm.163.7.2011060. - DOI - PubMed

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Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell

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Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell

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Conflict of interest statement

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Abstract

Conflict of interest statement

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