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Review
. 2024 Mar;55(1):26-40.
doi: 10.1007/s12029-023-00911-w. Epub 2023 Jul 11.

The Role of Small Interfering RNAs in Hepatocellular Carcinoma

Feng Chen  1 , Wang Zhang  1 , Xinran Gao  1 , Hui Yuan  1 , Kehai Liu  2
Affiliations
Review

The Role of Small Interfering RNAs in Hepatocellular Carcinoma

Feng Chen et al. J Gastrointest Cancer. 2024 Mar.

Abstract

Background: Hepatocellular carcinoma (HCC), a primary liver cancer with high mortality, is the most common malignant tumor in the world. Currently, the effect of routine treatment is poor, especially for this kind of cancer with strong heterogeneity and late detection. In the past decades, the researches of gene therapy for HCC based on small interfering RNA have blossomed everywhere. This is a promising therapeutic strategy, but the application of siRNA is limited by the discovery of effective molecular _targets and the delivery system _targeting HCC. As the deepening of research, scientists have developed many effective delivery systems and found more new therapeutic _targets.

Conclusions: This paper mainly reviews the research on HCC treatment based on siRNA in recent years, and summarizes and classifies the HCC treatment _targets and siRNA delivery systems.

Keywords: Cancer; Gene therapy; Hepatocellular carcinoma; Small interfering RNA.

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