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Review
. 2023 Nov;66(11):1961-1970.
doi: 10.1007/s00125-023-05965-w. Epub 2023 Jul 13.

An unwelcome inheritance: childhood obesity after diabetes in pregnancy

Claire L Meek  1   2
Affiliations
Review

An unwelcome inheritance: childhood obesity after diabetes in pregnancy

Claire L Meek. Diabetologia. 2023 Nov.

Abstract

Diabetes in pregnancy affects 20 million women per year and is associated with increased risk of obesity in offspring, leading to insulin resistance and cardiometabolic disease. Despite the substantial public health ramifications, relatively little is known about the pathophysiological mechanisms underlying obesity in these high-risk children, which creates a barrier to successful intervention. While maternal glucose itself is undeniably a major stimulus upon intrauterine growth, the degree of offspring hyperinsulinism and disturbed lipid metabolism in mothers and offspring are also likely to be implicated in the disease process. The aim of this review is to summarise current understanding of the pathophysiology of childhood obesity after intrauterine exposure to maternal hyperglycaemia and to highlight possible opportunities for intervention. I present here a new unified hypothesis for the pathophysiology of childhood obesity in infants born to mothers with diabetes, which involves self-perpetuating twin cycles of pancreatic beta cell hyperfunction and altered lipid metabolism, both acutely and chronically upregulated by intrauterine exposure to maternal hyperglycaemia.

Keywords: Childhood obesity; Gestational diabetes; Metabolism; Pregnancy; Review.

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Figures

Fig. 1
Fig. 1
A unifying hypothesis for the development of large-for-gestational-age and childhood obesity after exposure to intrauterine hyperglycaemia. Hypothesis: the developmental effects of maternal hyperglycaemia upon childhood obesity are mediated directly or indirectly through altered offspring lipid metabolism/distribution and increased offspring pancreatic function from birth. These factors exert short-term effects upon body composition but also chronically upregulate key pathways in postnatal life (the lipid cycle and pancreatic cycle), resulting in obesity and cardiometabolic disease. This figure is available as a downloadable slide
See this image and copyright information in PMC

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