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Review
. 2024 Mar;50(2):224-240.
doi: 10.1080/1040841X.2023.2294904. Epub 2023 Dec 28.

Activation of host nucleic acid sensors by Mycobacterium: good for us or good for them?

Jeffrey S Schorey  1 , Joseph Vecchio  1 , William R McManus  1 , Joshua Ongalo  1 , Kylie Webber  1
Affiliations
Review

Activation of host nucleic acid sensors by Mycobacterium: good for us or good for them?

Jeffrey S Schorey et al. Crit Rev Microbiol. 2024 Mar.

Abstract

Although the importance of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) sensors in controlling viral infection is well established, their role in promoting an effective immune response to pathogens other than viruses is less clear. This is particularly true for infections with mycobacteria, as studies point to both protective and detrimental roles for activation of nucleic acid sensors in controlling a mycobacterial infection. Some of the contradiction likely stems from the use of different model systems and different mycobacterial species/strains as well as from which nucleic acid sensors were studied and what downstream effectors were evaluated. In this review, we will describe the different nucleic acid sensors that have been studied in the context of mycobacterial infections, and how the different studies compare. We conclude with a section on how nucleic acid sensor agonists have been used therapeutically and what further information is needed to enhance their potential as therapeutic agents.

Keywords: DNA sensors; Mycobacterium; RNA sensors; therapeutics.

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Conflict of interest statement

Disclosure statement. The authors report there are no competing interests to declare.

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