Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

doi:10.7717/peerj.17267

Review

. 2024 Apr 29:12:e17267.

doi: 10.7717/peerj.17267. eCollection 2024.

Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

Nihong Zhou^{1

2}, Lijing Gong^{1

3}, Enming Zhang^{4

5}, Xintang Wang^{3

6}

Affiliations

¹ Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, China.
² School of Sport Science, Beijing Sport University, Beijing, China.
³ Key Laboratory for Performance Training & Recovery of General Administration of Sport, Beijing Sport University, Beijing, China.
⁴ Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
⁵ NanoLund Center for NanoScience, Lund University, Lund, Sweden.
⁶ China Institute of Sport and Health Science, Beijing Sport University, Beijing, China.

PMID: 38699186
PMCID: PMC11064867
DOI: 10.7717/peerj.17267

Review

Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

Nihong Zhou et al. PeerJ. 2024.

. 2024 Apr 29:12:e17267.

doi: 10.7717/peerj.17267. eCollection 2024.

Authors

Nihong Zhou^{1

2}, Lijing Gong^{1

3}, Enming Zhang^{4

5}, Xintang Wang^{3

6}

Affiliations

¹ Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, China.
² School of Sport Science, Beijing Sport University, Beijing, China.
³ Key Laboratory for Performance Training & Recovery of General Administration of Sport, Beijing Sport University, Beijing, China.
⁴ Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
⁵ NanoLund Center for NanoScience, Lund University, Lund, Sweden.
⁶ China Institute of Sport and Health Science, Beijing Sport University, Beijing, China.

PMID: 38699186
PMCID: PMC11064867
DOI: 10.7717/peerj.17267

Abstract

Exercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs and tissues in response to exercise stimuli and are widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular tissue, kidney, and bone. For the metabolic effect, exerkines regulate the metabolic homeostasis of organisms by increasing glucose uptake and improving fat synthesis. For the anti-inflammatory effect, exerkines positively influence various chronic inflammation-related diseases, such as type 2 diabetes and atherosclerosis. This review highlights the prospective contribution of exerkines in regulating metabolism, augmenting the anti-inflammatory effects, and providing additional advantages associated with exercise. Moreover, a comprehensive overview and analysis of recent advancements are provided in this review, in addition to predicting future applications used as a potential biomarker or therapeutic _target to benefit patients with chronic diseases.

Keywords: Chronic diseases; Exercise factors; Exerkines; Inflammation; Metabolism.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

**Figure 1. The effects of exercise-induced exerkines on tissues and organs.**
Arrows indicate: ↑, possible promoting effect; ↓, possible inhibiting effect.

See this image and copyright information in PMC

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[1] Afsar B, Afsar RE. Brain-derived neurotrophic factor (BDNF): a multifaceted marker in chronic kidney disease. Clinical and Experimental Nephrology. 2022;26(12):1149–1159. doi: 10.1007/s10157-022-02268-z. - DOI - PubMed

[2] Afsar B, Afsar RE. Brain-derived neurotrophic factor (BDNF): a multifaceted marker in chronic kidney disease. Clinical and Experimental Nephrology. 2022;26(12):1149–1159. doi: 10.1007/s10157-022-02268-z. - DOI - PubMed

[3] Ahuja P, Ng CF, Pang BPS, Chan WS, Tse MCL, Bi X, Kwan HR, Brobst D, Herlea-Pana O, Yang X, Du G, Saengnipanthkul S, Noh HL, Jiao B, Kim JK, Lee CW, Ye K, Chan CB. Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice. Autophagy. 2022;18(6):1367–1384. doi: 10.1080/15548627.2021.1985257. - DOI - PMC - PubMed

[4] Ahuja P, Ng CF, Pang BPS, Chan WS, Tse MCL, Bi X, Kwan HR, Brobst D, Herlea-Pana O, Yang X, Du G, Saengnipanthkul S, Noh HL, Jiao B, Kim JK, Lee CW, Ye K, Chan CB. Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice. Autophagy. 2022;18(6):1367–1384. doi: 10.1080/15548627.2021.1985257. - DOI - PMC - PubMed

[5] Allen DL, Hittel DS, McPherron AC. Expression and function of myostatin in obesity, diabetes, and exercise adaptation. Medicine & Science in Sports & Exercise. 2011;43(10):1828–1835. doi: 10.1249/MSS.0b013e3182178bb4. - DOI - PMC - PubMed

[6] Allen DL, Hittel DS, McPherron AC. Expression and function of myostatin in obesity, diabetes, and exercise adaptation. Medicine & Science in Sports & Exercise. 2011;43(10):1828–1835. doi: 10.1249/MSS.0b013e3182178bb4. - DOI - PMC - PubMed

[7] Aoi W, Hirano N, Lassiter DG, Björnholm M, Chibalin AV, Sakuma K, Tanimura Y, Mizushima K, Takagi T, Naito Y, Zierath JR, Krook A. Secreted protein acidic and rich in cysteine (SPARC) improves glucose tolerance via AMP-activated protein kinase activation. The FASEB Journal. 2019;33(9):10551–10562. doi: 10.1096/fj.201900453R. - DOI - PubMed

[8] Aoi W, Hirano N, Lassiter DG, Björnholm M, Chibalin AV, Sakuma K, Tanimura Y, Mizushima K, Takagi T, Naito Y, Zierath JR, Krook A. Secreted protein acidic and rich in cysteine (SPARC) improves glucose tolerance via AMP-activated protein kinase activation. The FASEB Journal. 2019;33(9):10551–10562. doi: 10.1096/fj.201900453R. - DOI - PubMed

[9] Archundia-Herrera C, Macias-Cervantes M, Ruiz-Muñoz B, Vargas-Ortiz K, Kornhauser C, Perez-Vazquez V. Muscle irisin response to aerobic vs HIIT in overweight female adolescents. Diabetology & Metabolic Syndrome. 2017;9:101. doi: 10.1186/s13098-017-0302-5. - DOI - PMC - PubMed

[10] Archundia-Herrera C, Macias-Cervantes M, Ruiz-Muñoz B, Vargas-Ortiz K, Kornhauser C, Perez-Vazquez V. Muscle irisin response to aerobic vs HIIT in overweight female adolescents. Diabetology & Metabolic Syndrome. 2017;9:101. doi: 10.1186/s13098-017-0302-5. - DOI - PMC - PubMed

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Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

Affiliations

Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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Cited by

References

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Medical

Abstract

Conflict of interest statement

Figures

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