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Review
. 2024 May:92:101033.
doi: 10.1016/j.jbior.2024.101033. Epub 2024 May 9.

Decoding how receptor tyrosine kinases (RTKs) mediate nuclear calcium signaling

María José González Armijos  1 , Thais Fernandes Bassani  1 , Clara Couto Fernandez  1 , Michele Angela Rodrigues  1 , Dawidson Assis Gomes  2
Affiliations
Review

Decoding how receptor tyrosine kinases (RTKs) mediate nuclear calcium signaling

María José González Armijos et al. Adv Biol Regul. 2024 May.

Abstract

Calcium (Ca2+) is a highly versatile intracellular messenger that regulates several cellular processes. Although it is unclear how a single-second messenger coordinates various effects within a cell, there is growing evidence that spatial patterns of Ca2+ signals play an essential role in determining their specificity. Ca2+ signaling patterns can differ in various cell regions, and Ca2+ signals in the nuclear and cytoplasmic compartments have been observed to occur independently. The initiation and function of Ca2+ signaling within the nucleus are not yet fully understood. Receptor tyrosine kinases (RTKs) induce Ca2+ signaling resulting from phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis and inositol 1,4,5-trisphosphate (InsP3) formation within the nucleus. This signaling mechanism may be responsible for the effects of specific growth factors on cell proliferation and gene transcription. This review highlights the recent advances in RTK trafficking to the nucleus and explains how these receptors initiate nuclear calcium signaling.

Keywords: Calcium signaling; Nuclear calcium; Nucleoplasmic reticulum; Nucleus; Phospholipase C; Receptor tyrosine kinases.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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