Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct;183(10):4169-4178.
doi: 10.1007/s00431-024-05712-2. Epub 2024 Aug 7.

Early EEG and NIRS measurements in preterm babies: a systematic review

R Llamas-Ramos  1   2 , J J Alvarado-Omenat  3 , I Llamas-Ramos  4   5   6   7
Affiliations

Early EEG and NIRS measurements in preterm babies: a systematic review

R Llamas-Ramos et al. Eur J Pediatr. 2024 Oct.

Abstract

Preterm birth represents a public health problem, with prematurity being the leading cause of infant mortality. An objective brain maturation and oxygenation measurement are necessary. The objective has been To test the feasibility of EEG and NIRS combination in the assessment of physiological brain maturation and oxygenation in preterm and non-preterm babies. A systematic review in Pubmed, Web of Science, MEDLINE, Cochrane, Dialnet, CINAHL, Scopus, Lilacs and PEDro databases until December 2022 was developed. 598 registers were found, finally 5 of them reached the inclusion criteria. Two independent reviewers analyzed data and a third reviewer were available for discrepancies. All articles combined EEG and NIRS to assess brain oxygenation and maturation in healthy new-born babies. There is an agreement on the electrode's placement for EEG at P3 and P4; besides, these regions have been shown to be a development predictive area, as well as the frontoparietal region for the NIRS region and comparison between regions. There is little evidence about the physiological brain electrical activity and oxygenation without stimuli.Conclusion: EEG and NIRS have been useful to assess brain electrical activity and oxygenation in preterm and non-preterm. The combined measurement of these instruments could be essential in neurological disorders diagnosis or their sequels. Unfortunately, the heterogeneity of the results found prevents a consensus on which variables are the most appropriate for the assessment of this population. What is Known • Brain assessment could help clinicians to prevent sequels. • There is an agreement for EEG electrodes placement at P3 and P4 region. What is New • EEG and NIRS assessment are effective measurements for preterm babies. • P3 and P4 regions have shown to be a predictive area of development, as well as the frontoparietal region for NIRS assessment.

Keywords: Assessment; EEG; NIRS; Preterm.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flowchart of article selection
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. van 't Westende C, Peeters-Scholte CMPCD, Jansen L, van Egmond-van Dam JC, Tannemaat MR, de Bruïne FT, et al (2020) The degree of prematurity affects functional brain activity in preterm born children at school-age: an EEG study. Early Hum Dev. 48, 105096. 10.1016/j.earlhumdev.2020.105096 - PubMed
    1. Patel RM (2016) Short- and long-term outcomes for extremely preterm infants. Am J Perinatol 33:318–328 - PMC - PubMed
    1. WHO (2012) March of Dimes, PMNCH, Save the children. in born too soon: the global action report on preterm birth;World Health Organization: Geneva, Switzerland
    1. Goldenberg RL, Culhane JF, Iams JD, Romero R (2008) Epidemiology and causes of preterm birth. Lancet 371:75–84 - PMC - PubMed
    1. Gyamfi-Bannerman C, Fuchs KM, Young OM, Hoffman MK (2011) Nonspontaneous late preterm birth: etiology and outcomes. Am J Obstet Gynecol 205(456):e1-6 - PubMed

Publication types

LinkOut - more resources

  NODES
twitter 2