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Review
. 2024 Nov:229:116470.
doi: 10.1016/j.bcp.2024.116470. Epub 2024 Aug 8.

CDK9 inhibitors for the treatment of solid tumors

Affiliations
Review

CDK9 inhibitors for the treatment of solid tumors

Christiana Mo et al. Biochem Pharmacol. 2024 Nov.

Abstract

Cyclin-dependent kinase 9 (CDK9) regulates mRNA transcription by promoting RNA Pol II elongation. CDK9 is now emerging as a potential therapeutic _target for cancer, since its overexpression has been found to correlate with cancer development and worse clinical outcomes. While much work on CDK9 inhibition has focused on hematologic malignancies, the role of this cancer driver in solid tumors is starting to come into focus. Many solid cancers also overexpress CDK9 and depend on its activity to promote downstream oncogenic signaling pathways. In this review, we summarize the latest knowledge of CDK9 biology in solid tumors and the studies of small molecule CDK9 inhibitors. We discuss the results of the latest clinical trials of CDK9 inhibitors in solid tumors, with a focus on key issues to consider for improving the therapeutic impact of this drug class.

Keywords: CDK9; Cancer therapeutics; Solid tumors; _targeted therapy.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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