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Review
. 2024;25(9):708-718.
doi: 10.2174/0113892037292440240518194922.

An Overview of the Deubiquitinase USP53: A Promising Diagnostic Marker and Therapeutic _target

Guangce Xia  1   2 , Yulin Guo  1   2 , Jiajia Zhang  1 , Meng Han  3 , Xiangchao Meng  3 , Ji Lv  3
Affiliations
Review

An Overview of the Deubiquitinase USP53: A Promising Diagnostic Marker and Therapeutic _target

Guangce Xia et al. Curr Protein Pept Sci. 2024.

Abstract

Ubiquitination and deubiquitination are important mechanisms to maintain normal physiological activities, and their disorders or imbalances can lead to various diseases. As a subgroup of deubiquitinases (DUBs), the ubiquitin-specific peptidase (USP) family is closely related to many biological processes. USP53, one of the family members, is widely expressed in human tissues and participates in a variety of life activities, such as cell apoptosis, nerve transmission, and bone remodeling. Mutations in the USP53 gene can cause cholestasis and deafness and may also be a potential cause of schizophrenia. Knockout of USP53 can alleviate neuropathic pain induced by chronic constriction injury. Loss of USP53 up-regulates RANKL expression, promotes the cytogenesis and functional activity of osteoclasts, and triggers osteodestructive diseases. USP53 plays a tumor-suppressive role in lung cancer, renal clear cell carcinoma, colorectal cancer, liver cancer, and esophageal cancer but reduces the radiosensitivity of cervical cancer and esophageal cancer to induce radioresistance. Through the in-depth combination of literature and bioinformatics, this review suggested that USP53 may be a good potential biomarker or therapeutic _target for diseases.

Keywords: USP53; bioinformatics.; deubiquitinase; diagnostic marker; therapeutic _target; ubiquitination.

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Conflict of interest statement

The author(s) declare no conflict of interest, financial or otherwise.

Figures

Fig. (1)
Fig. (1)
Biological process of ubiquitination and deubiquitination: their interaction maintains the homeostasis of proteins and free ubiquitin in the organism.
Fig. (2)
Fig. (2)
USP domain: It looks like an open right hand.
Fig. (3)
Fig. (3)
The network of interactions between USP53 and other genes.
Fig. (4)
Fig. (4)
Structure of USP53: the predicted binding sites are shown in red.
Fig. (5)
Fig. (5)
Distribution of USP53 in human tissues.
See this image and copyright information in PMC

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