Alternation behavior, spatial discrimination, and reversal disturbances following 6-hydroxydopamine lesions in the nucleus accumbens of the rat
- PMID: 3936470
- DOI: 10.1016/s0163-1047(85)90640-5
Alternation behavior, spatial discrimination, and reversal disturbances following 6-hydroxydopamine lesions in the nucleus accumbens of the rat
Abstract
The effects of dopaminergic depletion of the nucleus accumbens was tested in various behavioral tasks such as alternation, spatial discrimination, and reversal learning, and in an extinction paradigm in a T maze. Animals with lesions showed impairment of spontaneous alternation behavior, disturbances in the acquisition of spatial discrimination, and great difficulty in reversing previously learned habits. In the extinction phase, experimental animals are unable to adjust their behavior, and continue to choose the previously reinforced arm of the T maze. It is suggested that the nucleus accumbens plays an important role in the transition of motivation into action, and that dopamine has a facilitatory influence on the mediation of these processes.
Similar articles
-
The effects of ibotenic acid lesions of the nucleus accumbens on spatial learning and extinction in the rat.Behav Brain Res. 1989 Jan 1;31(3):231-42. doi: 10.1016/0166-4328(89)90005-3. Behav Brain Res. 1989. PMID: 2914074
-
Mesolimbic dopamine lesions produce an augmented behavioral response to enkephalin.Neuropharmacology. 1985 Oct;24(10):931-6. doi: 10.1016/0028-3908(85)90117-0. Neuropharmacology. 1985. PMID: 3934576
-
Effects of ventro-medial mesencephalic tegmentum (VMT) stimulation on the spontaneous activity of nucleus accumbens neurones: influence of the dopamine system.Brain Res. 1986 Jan 22;363(2):290-8. doi: 10.1016/0006-8993(86)91014-0. Brain Res. 1986. PMID: 3002556
-
Comparative functions of the central noradrenergic, dopaminergic and cholinergic systems.Neuropharmacology. 1987 Jul;26(7B):893-901. doi: 10.1016/0028-3908(87)90067-0. Neuropharmacology. 1987. PMID: 3116447 Review.
-
Functional studies of the central catecholamines.Int Rev Neurobiol. 1982;23:303-65. doi: 10.1016/s0074-7742(08)60628-5. Int Rev Neurobiol. 1982. PMID: 6749738 Review. No abstract available.
Cited by
-
Dissociable responses to punishment in distinct striatal regions during reversal learning.Neuroimage. 2010 Jul 15;51(4):1459-67. doi: 10.1016/j.neuroimage.2010.03.036. Epub 2010 Mar 18. Neuroimage. 2010. PMID: 20303408 Free PMC article.
-
Dopamine DRD2 polymorphism alters reversal learning and associated neural activity.J Neurosci. 2009 Mar 25;29(12):3695-704. doi: 10.1523/JNEUROSCI.5195-08.2009. J Neurosci. 2009. PMID: 19321766 Free PMC article.
-
Motivational states influence effort-based decision making in rats: the role of dopamine in the nucleus accumbens.Cogn Affect Behav Neurosci. 2012 Mar;12(1):74-84. doi: 10.3758/s13415-011-0068-4. Cogn Affect Behav Neurosci. 2012. PMID: 22012275
-
Problem Solving in Animals: Proposal for an Ontogenetic Perspective.Animals (Basel). 2021 Mar 18;11(3):866. doi: 10.3390/ani11030866. Animals (Basel). 2021. PMID: 33803609 Free PMC article. Review.
-
Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies.Neuron. 2020 Aug 19;107(4):731-744.e3. doi: 10.1016/j.neuron.2020.05.023. Epub 2020 Jun 10. Neuron. 2020. PMID: 32526196 Free PMC article.