Comparative Study
doi: 10.1038/298447a0.
Homology among DNA-binding proteins suggests use of a conserved super-secondary structure
- PMID: 6896364
- DOI: 10.1038/298447a0
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Comparative Study
Homology among DNA-binding proteins suggests use of a conserved super-secondary structure
Nature.
.
Abstract
The amino acid sequences of the repressor and cro proteins of phages lambda, 434 and P22 are homologous, especially in a region in which repressor and lambda cro have a similar alpha-helix-turn-alpha-helix secondary structure. Model-building studies indicate that this structure is important in DNA binding, and we suggest it may be a common feature of many DNa-binding proteins.
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