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. 1993 Dec 24;262(5142):2045-50.
doi: 10.1126/science.7903479.

T cell activation antigen, CD26, as a cofactor for entry of HIV in CD4+ cells

C Callebaut  1 , B Krust, E Jacotot, A G Hovanessian
Affiliations

T cell activation antigen, CD26, as a cofactor for entry of HIV in CD4+ cells

C Callebaut et al. Science. .

Abstract

The CD4 molecule is essential for binding HIV particles, but is not sufficient for efficient viral entry and infection. The cofactor was shown to be dipeptidyl peptidase IV (DPP IV), also known as CD26. This serine protease cleaves its substrates at specific motifs; such motifs area also highly conserved in the V3 loops of HIV-1, HIV-2, and related simian isolates. Entry of HIV-1 or HIV-2 into T lymphoblastoid and monocytoid cell lines was inhibited by a specific monoclonal antibody against DPP IV or specific peptide inhibitors of this protease. Coexpression of human CD4 and CD26 in murine NIH 3T3 cells rendered them permissive to infection by HIV-1 and HIV-2. These observations could provide the basis for developing simple and specific inhibitors of HIV and open a possibility for vaccine development.

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Comment in

  • HIV 'cofactor' comes in for more heavy fire.
    Cohen J. Cohen J. Science. 1993 Dec 24;262(5142):1971. doi: 10.1126/science.7903478. Science. 1993. PMID: 7903478 No abstract available.
  • CD26 antigen and HIV fusion?
    Broder CC, Nussbaum O, Gutheil WG, Bachovchin WW, Berger EA. Broder CC, et al. Science. 1994 May 20;264(5162):1156-9; author reply 1162-5. doi: 10.1126/science.7909959. Science. 1994. PMID: 7909959 No abstract available.
  • CD26 antigen and HIV fusion?
    Patience C, McKnight A, Clapham PR, Boyd MT, Weiss RA, Schulz TF. Patience C, et al. Science. 1994 May 20;264(5162):1159-60; author reply 1162-5. doi: 10.1126/science.7909960. Science. 1994. PMID: 7909960 No abstract available.
  • CD26 antigen and HIV fusion?
    Camerini D, Planelles V, Chen IS. Camerini D, et al. Science. 1994 May 20;264(5162):1160-1; author reply 1162-5. doi: 10.1126/science.7909961. Science. 1994. PMID: 7909961 No abstract available.
  • CD26 antigen and HIV fusion?
    Alizon M, Dragic T. Alizon M, et al. Science. 1994 May 20;264(5162):1161-2; author reply 1162-5. doi: 10.1126/science.7909962. Science. 1994. PMID: 7909962 No abstract available.

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