NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway
- PMID: 8096091
- DOI: 10.1126/science.8096091
NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway
Abstract
The eukaryotic transcription factor nuclear factor-kappa B (NF-kappa B) participates in many parts of the genetic program mediating T lymphocyte activation and growth. Nuclear expression of NF-kappa B occurs after its induced dissociation from its cytoplasmic inhibitor I kappa B alpha. Phorbol ester and tumor necrosis factor-alpha induction of nuclear NF-kappa B is associated with both the degradation of performed I kappa B alpha and the activation of I kappa B alpha gene expression. Transfection studies indicate that the I kappa B alpha gene is specifically induced by the 65-kilodalton transactivating subunit of NF-kappa B. Association of the newly synthesized I kappa B alpha with p65 restores intracellular inhibition of NF-kappa B DNA binding activity and prolongs the survival of this labile inhibitor. Together, these results show that NF-kappa B controls the expression of I kappa B alpha by means of an inducible autoregulatory pathway.
Similar articles
-
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2532-6. doi: 10.1073/pnas.90.6.2532. Proc Natl Acad Sci U S A. 1993. PMID: 8460169 Free PMC article.
-
Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.Cancer Res. 1994 Mar 15;54(6):1425-30. Cancer Res. 1994. PMID: 8137243
-
Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3.J Virol. 1994 Dec;68(12):8035-44. doi: 10.1128/JVI.68.12.8035-8044.1994. J Virol. 1994. PMID: 7966593 Free PMC article.
-
[Nuclear transcription factor kappa B (NF-kappa B)].Rev Med Interne. 1998 Dec;19(12):945-7. doi: 10.1016/s0248-8663(99)80074-5. Rev Med Interne. 1998. PMID: 9887469 Review. French.
-
Function and activation of the transcription factor NF-kappa B in the response to toxins and pathogens.Toxicol Lett. 1995 Dec;82-83:407-11. doi: 10.1016/0378-4274(95)03491-9. Toxicol Lett. 1995. PMID: 8597085 Review.
Cited by
-
Discrete signal transduction pathway utilization by a neuropeptide (PACAP) and a cytokine (TNF-alpha) first messenger in chromaffin cells, inferred from coupled transcriptome-promoter analysis of regulated gene cohorts.Peptides. 2013 Jul;45:48-60. doi: 10.1016/j.peptides.2013.03.020. Epub 2013 Apr 19. Peptides. 2013. PMID: 23608709 Free PMC article.
-
TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro.Arthritis Res Ther. 2012 Nov 7;14(6):R242. doi: 10.1186/ar4085. Arthritis Res Ther. 2012. PMID: 23134577 Free PMC article.
-
HIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO2 Production and Neurotoxic Activity.PLoS One. 2015 Jun 11;10(6):e0130189. doi: 10.1371/journal.pone.0130189. eCollection 2015. PLoS One. 2015. PMID: 26066624 Free PMC article.
-
Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss.Mol Cell Biol. 2006 Feb;26(3):1038-50. doi: 10.1128/MCB.26.3.1038-1050.2006. Mol Cell Biol. 2006. PMID: 16428456 Free PMC article.
-
Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-kappaB- and p53-regulated gene _targets.Cell Death Differ. 2007 Sep;14(9):1700-10. doi: 10.1038/sj.cdd.4402172. Epub 2007 Jun 29. Cell Death Differ. 2007. PMID: 17599100 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
