doi: 10.1002/eji.1830231049.
Age-related increase of CD45RO+ lymphocytes in physically active adults
Affiliations
- PMID: 8104800
- DOI: 10.1002/eji.1830231049
Item in Clipboard
Age-related increase of CD45RO+ lymphocytes in physically active adults
Eur J Immunol.
1993 Oct.
Abstract
The CD45RO phenotype of peripheral blood CD4+ and CD8+ lymphocytes were determined in physically active males (n = 171) and females (n = 70) ranging in age from 15-68 years. Direct immunofluorescence and dual color flow cytometry was performed for analysis. Absolute cell numbers (r = 0.473) and percentages of CD4+ CD45RO+ (r = 0.648) within the CD4+ population, percentage of CD8+ CD45RO+ cells within the CD8+ lymphocytes (r = 0.498) and total lymphocyte number (r = -0.242) correlated significantly (p < 0.001) with age. We conclude that the age-related increase of CD45RO+ T cells indicates a gradual increase of activated T cells.
Similar articles
-
Reference values for CD4+ and CD8+ T lymphocytes with naïve or memory phenotype and their association with mortality in the elderly.Gerontology. 2009;55(3):314-21. doi: 10.1159/000199451. Epub 2009 Feb 4. Gerontology. 2009. PMID: 19190395
-
Flow cytometric characterization of human umbilical cord blood lymphocytes: immunophenotypic features.Haematologica. 1998 Mar;83(3):197-203. Haematologica. 1998. PMID: 9573672
-
Postthymic development of CD28-CD8+ T cell subset: age-associated expansion and shift from memory to naive phenotype.J Immunol. 1999 Mar 15;162(6):3327-35. J Immunol. 1999. PMID: 10092786
-
CD4+ and CD8+ lymphocyte and cortisol response patterns in elderly and young males after methylprednisolone exposure.J Med. 1998;29(3-4):159-83. J Med. 1998. PMID: 9865456 Clinical Trial.
-
Analysis of recently activated, memory and naive lymphocyte T subsets in the peripheral blood of patients with Graves' disease and insulin-dependent diabetes mellitus.Rocz Akad Med Bialymst. 1999;44:226-34. Rocz Akad Med Bialymst. 1999. PMID: 10697437
Cited by
-
Molecular alterations in the aging immune system.J Exp Med. 1995 Jul 1;182(1):1-3. doi: 10.1084/jem.182.1.1. J Exp Med. 1995. PMID: 7540645 Free PMC article. No abstract available.
-
Aging affects the proportions of T and B cells in a group of elderly men in a developing country--a pilot study from Pakistan.Age (Dordr). 2013 Oct;35(5):1521-30. doi: 10.1007/s11357-012-9455-1. Epub 2012 Jul 19. Age (Dordr). 2013. PMID: 22810104 Free PMC article.
-
High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis.Front Immunol. 2018 Oct 31;9:2519. doi: 10.3389/fimmu.2018.02519. eCollection 2018. Front Immunol. 2018. PMID: 30429855 Free PMC article.
-
Human T-cell responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine.Infect Immun. 1998 Mar;66(3):959-65. doi: 10.1128/IAI.66.3.959-965.1998. Infect Immun. 1998. PMID: 9488382 Free PMC article.
-
Maintenance of size and function of influenza virus hemagglutinin specific transgenic T-cell clone during life.J Cell Mol Med. 2001 Oct-Dec;5(4):388-96. doi: 10.1111/j.1582-4934.2001.tb00173.x. J Cell Mol Med. 2001. PMID: 12067472 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
