Fluconazole-resistant Candida albicans
- PMID: 8110924
- DOI: 10.1093/clinids/17.6.1018
Fluconazole-resistant Candida albicans
Abstract
Mucocutaneous candidiasis caused by Candida albicans is a common complication of human immunodeficiency virus (HIV) infection. Recent reports of isolation of resistant strains of C. albicans raise the specter of more widespread resistance, but limited series are available to analyze situations in which the likelihood of resistance is greatest. We present our experience with fluconazole-resistant candidiasis in patients with HIV infection obtained from retrospective chart review and by testing strains of C. albicans isolated during relapse for susceptibility to antifungal agents. The possible reasons for failure of antifungal therapy are discussed, as well the correlation between in vivo and in vitro data. Resistant candidiasis in patients with HIV disease is an emerging problem of considerable concern that merits further study.
Similar articles
-
Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug.FEMS Microbiol Lett. 1995 Sep 15;131(3):337-41. doi: 10.1111/j.1574-6968.1995.tb07797.x. FEMS Microbiol Lett. 1995. PMID: 7557345
-
Clearance of a fluconazole-resistant Candida albicans strain after switching antifungal therapy and initiation of triple therapy for HIV infection.Clin Microbiol Infect. 2000 Apr;6(4):220-3. doi: 10.1046/j.1469-0691.2000.00041-1.x. Clin Microbiol Infect. 2000. PMID: 11168112 No abstract available.
-
Fluconazole susceptibility and strain variation of Candida albicans isolates from HIV-infected patients with oropharyngeal candidosis.J Antimicrob Chemother. 1998 May;41(5):541-8. doi: 10.1093/jac/41.5.541. J Antimicrob Chemother. 1998. PMID: 9630407 Clinical Trial.
-
Triazole therapy for mucocutaneous candidiasis in HIV-infected patients.J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):36-44. doi: 10.1016/S1055-3290(98)80031-9. J Assoc Nurses AIDS Care. 1998. PMID: 9742479 Review.
-
Resistant candidiasis.AIDS Res Hum Retroviruses. 1994 Aug;10(8):925-9. doi: 10.1089/aid.1994.10.925. AIDS Res Hum Retroviruses. 1994. PMID: 7811544 Review.
Cited by
-
Patterns of in vitro activity of itraconazole and imidazole antifungal agents against Candida albicans with decreased susceptibility to fluconazole from Spain.Antimicrob Agents Chemother. 1995 Jul;39(7):1512-6. doi: 10.1128/AAC.39.7.1512. Antimicrob Agents Chemother. 1995. PMID: 7492095 Free PMC article.
-
Comparative evaluation of macrodilution and alamar colorimetric microdilution broth methods for antifungal susceptibility testing of yeast isolates.J Clin Microbiol. 1995 Oct;33(10):2660-4. doi: 10.1128/jcm.33.10.2660-2664.1995. J Clin Microbiol. 1995. PMID: 8567901 Free PMC article.
-
In vitro activities of terbinafine in combination with fluconazole and itraconazole against isolates of Candida albicans with reduced susceptibility to azoles.Antimicrob Agents Chemother. 1997 Aug;41(8):1812-4. doi: 10.1128/AAC.41.8.1812. Antimicrob Agents Chemother. 1997. PMID: 9257768 Free PMC article.
-
Membrane fluidity and lipid composition of fluconazole resistant and susceptible strains of Candida albicans isolated from diabetic patients.Braz J Microbiol. 2008 Apr;39(2):219-25. doi: 10.1590/S1517-83822008000200004. Epub 2008 Jun 1. Braz J Microbiol. 2008. PMID: 24031205 Free PMC article.
-
Epidemiology of infections in cancer patients.Cancer Treat Res. 2014;161:43-89. doi: 10.1007/978-3-319-04220-6_2. Cancer Treat Res. 2014. PMID: 24706221 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
