Fornix degeneration and memory in traumatic brain injury
- PMID: 8221124
- DOI: 10.1016/0361-9230(93)90198-k
Fornix degeneration and memory in traumatic brain injury
Abstract
Fornix-to-brain ratios (FBR) based on postinjury magnetic resonance (MR) studies were calculated on a group of 27 female traumatic brain injury (TBI) patients and 18 female medical controls by taking the widest aspect of the fornix at the level of the anterior horns and third ventricle and determining a fornix surface area. The FBR was significantly reduced in the TBI group (FBR = 0.1121) as compared to the normal control group (FBR = 0.1766). Despite these significant FBR findings indicating prominent atrophic changes of the fornix in TBI patients, the FBR did not relate systematically to neuropsychological outcome. These findings clearly indicate fornix vulnerability in TBI and that current quantitative MR methods are sensitive enough to detect such changes. However, fornix degeneration constitutes only one of many contributing factors to the anatomic basis of TBI-induced cognitive disturbances, as fornix atrophy did not relate systematically to neuropsychological outcome.
Similar articles
-
Nonspecific white matter degeneration following traumatic brain injury.J Int Neuropsychol Soc. 1995 Jan;1(1):17-28. doi: 10.1017/s1355617700000060. J Int Neuropsychol Soc. 1995. PMID: 9375205
-
Fornix and hippocampal atrophy in traumatic brain injury.Learn Mem. 2000 Nov-Dec;7(6):442-6. doi: 10.1101/lm.33000. Learn Mem. 2000. PMID: 11112803
-
Verbal memory deficits associated with fornix atrophy in carbon monoxide poisoning.J Int Neuropsychol Soc. 2001 Jul;7(5):640-6. doi: 10.1017/s1355617701005112. J Int Neuropsychol Soc. 2001. PMID: 11459115
-
Quantitative magnetic resonance imaging in traumatic brain injury.J Head Trauma Rehabil. 2001 Apr;16(2):117-34. doi: 10.1097/00001199-200104000-00003. J Head Trauma Rehabil. 2001. PMID: 11275574 Review.
-
Neuropathology of Mild Traumatic Brain Injury: Correlation to Neurocognitive and Neurobehavioral Findings.In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 31. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 31. PMID: 26269912 Free Books & Documents. Review.
Cited by
-
Effects of age on the hippocampus and verbal memory in adults with autism spectrum disorder: Longitudinal versus cross-sectional findings.Autism Res. 2022 Oct;15(10):1810-1823. doi: 10.1002/aur.2797. Epub 2022 Aug 24. Autism Res. 2022. PMID: 36053945 Free PMC article.
-
The evolution of cost-efficiency in neural networks during recovery from traumatic brain injury.PLoS One. 2017 Apr 19;12(4):e0170541. doi: 10.1371/journal.pone.0170541. eCollection 2017. PLoS One. 2017. PMID: 28422992 Free PMC article.
-
Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury.Exp Neurol. 2009 Jan;215(1):119-27. doi: 10.1016/j.expneurol.2008.09.024. Epub 2008 Oct 11. Exp Neurol. 2009. PMID: 18977220 Free PMC article.
-
Gross morphology and morphometric sequelae in the hippocampus, fornix, and corpus callosum of patients with severe non-missile traumatic brain injury without macroscopically detectable lesions: a T1 weighted MRI study.J Neurol Neurosurg Psychiatry. 2004 Sep;75(9):1314-22. doi: 10.1136/jnnp.2003.017046. J Neurol Neurosurg Psychiatry. 2004. PMID: 15314123 Free PMC article.
-
Traumatic brain injury and grey matter concentration: a preliminary voxel based morphometry study.J Neurol Neurosurg Psychiatry. 2005 Jul;76(7):984-8. doi: 10.1136/jnnp.2004.036210. J Neurol Neurosurg Psychiatry. 2005. PMID: 15965207 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
