Review
doi: 10.1016/0168-9525(93)90089-z.
Mutagenesis by 8-oxoguanine: an enemy within
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- PMID: 8379000
- DOI: 10.1016/0168-9525(93)90089-z
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Review
Mutagenesis by 8-oxoguanine: an enemy within
Trends Genet.
1993 Jul.
Abstract
The presence of reactive oxygen species in cells ensures that the oxidatively damaged base 8-oxoguanine will be generated at high frequency in the DNA of all living organisms. DNA damage threatens genomic integrity: enzymes have evolved that protect prokaryotes and eukaryotes from the mutagenic effect of this ubiquitous lesion.
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