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. 1993 May 15;214(1):347-50.
doi: 10.1111/j.1432-1033.1993.tb17930.x.

Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour

P M Alliel  1 , J P Perin, P Jollès, F J Bonnet
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Free article

Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour

P M Alliel et al. Eur J Biochem. .
Free article

Abstract

The molecular characterization of a human testicular proteoglycan, the progenitor of a seminal plasma glycosaminoglycan-bearing peptide, was achieved by cDNA cloning. Its protein core encompasses several domains encountered in various proteins associated with adhesion, migration and cell proliferation. An osteonectin-like domain, a Kazal-like sequence and a 46-amino-acid motif around a Cys-Trp-Cys-Val peptide encountered in cell-surface antigens, cell-adhesion molecules and growth-factor-binding proteins are distributed within the testican protein core. Testican is the progenitor of the unique heparan/chondroitin-sulfate-bearing peptide present in human seminal plasma, a feature which might confer additional potentialities to this hybrid proteoglycan.

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