The influence of dietary n-3 fatty acids on plasma lipids and lipoproteins
- PMID: 8489156
- DOI: 10.1111/j.1749-6632.1993.tb38725.x
The influence of dietary n-3 fatty acids on plasma lipids and lipoproteins
Abstract
The body of epidemiologic data indicates that the incidence of cardiovascular disease is lower in populations whose habitual diet is rich in fish. It is unclear however to what extent this apparent protection is due to the intake of n-3 fatty acids in sea food or to the fact that these subjects have generally been consuming lower amounts of saturated fatty acids in their diets. It is clear, however, that when the dietary intake of n-3 fatty acids is increased to 4-8 g/day distinct metabolic effects are observed, including reductions in plasma triglycerides, effects on platelet function and coagulation factors and blood pressure. Larger intakes exert a more profound hypotriglyceridemic effect, and in patients with primary hypercholesterolemia daily intakes exceeding 10-12 g/day are effective in reducing plasma concentrations of LDL cholesterol. However, from a practical point of view, the lipid-modifying effects of supplemental dietary n-3 fatty acids are most clearly observed in patients with hypertriglyceridemia and the major usefulness of dietary n-3 fatty acids is in the treatment of this patient population, particularly patients with severe hypertriglyceridemia or potentially those with Type III hyperlipoproteinemia. Further studies are needed to better define the potential utility of dietary n-3 fatty acids when used in combination with lipid-lowering drugs to reduce lipoprotein concentrations in patients with combined hyperlipoproteinemia or severe hypertriglyceridemia.
Similar articles
-
N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients.Ann N Y Acad Sci. 1993 Jun 14;683:16-34. doi: 10.1111/j.1749-6632.1993.tb35689.x. Ann N Y Acad Sci. 1993. PMID: 8352438 Review.
-
Effects of modest doses of omega-3 fatty acids on lipids and lipoproteins in hypertriglyceridemic subjects. A randomized controlled trial.Arch Intern Med. 1989 Aug;149(8):1857-62. Arch Intern Med. 1989. PMID: 2669667 Clinical Trial.
-
n-3 fatty acid effects on lipids, lipoproteins, and apolipoproteins at very low doses: results of a randomized controlled trial in hypertriglyceridemic subjects.Am J Clin Nutr. 1990 Apr;51(4):599-605. doi: 10.1093/ajcn/51.4.599. Am J Clin Nutr. 1990. PMID: 2181859 Clinical Trial.
-
Olive oil, corn oil, and n-3 fatty acids differently affect lipids, lipoproteins, platelets, and superoxide formation in type II hypercholesterolemia.Am J Clin Nutr. 1992 Jul;56(1):113-22. doi: 10.1093/ajcn/56.1.113. Am J Clin Nutr. 1992. PMID: 1319109
-
The effects of n-3 fatty acids on plasma lipids and lipoproteins and other cardiovascular risk factors in patients with hyperlipidemia.Atherosclerosis. 1993 Nov;103(2):107-21. doi: 10.1016/0021-9150(93)90254-r. Atherosclerosis. 1993. PMID: 8292089 Review.
Cited by
-
Effect of royal jelly on serum lipids in experimental animals and humans with atherosclerosis.Experientia. 1995 Sep 29;51(9-10):927-35. doi: 10.1007/BF01921742. Experientia. 1995. PMID: 7556573 Review.
-
The Role of the Novel Lipokine Palmitoleic Acid in Health and Disease.Adv Nutr. 2017 Jan 17;8(1):173S-181S. doi: 10.3945/an.115.011130. Print 2017 Jan. Adv Nutr. 2017. PMID: 28096141 Free PMC article. Review.
-
The Effects of Linoleic Acid Consumption on Lipid Risk Markers for Cardiovascular Disease in Healthy Individuals: A Review of Human Intervention Trials.Nutrients. 2020 Aug 4;12(8):2329. doi: 10.3390/nu12082329. Nutrients. 2020. PMID: 32759714 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
