doi: 10.1038/363595a0.
Crystal structure of cyclin-dependent kinase 2
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- PMID: 8510751
- DOI: 10.1038/363595a0
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Crystal structure of cyclin-dependent kinase 2
Nature.
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Abstract
Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4 A resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix-loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.
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