Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Sep;38(9):1055-60.
doi: 10.1007/BF00402175.

Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase

Y Zhang  1 , M Warren-Perry, P J Saker, A T Hattersley, A D Mackie, J D Baird, R H Greenwood, M Stoffel, G I Bell, R C Turner
Affiliations

Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase

Y Zhang et al. Diabetologia. 1995 Sep.

Abstract

Maturity-onset diabetes of the young (MODY) is a form of non-insulin-dependent diabetes mellitus characterised by an early age of onset and an autosomal dominant mode of inheritance. Only a proportion of cases are due to mutations in the glucokinase gene. We have studied five Caucasian MODY families, including the first MODY family to be described, with five candidate genes implicated in regulation of insulin secretion. The affected subjects showed more marked hyperglycaemia than that found in subjects with glucokinase mutations. We assessed polymorphic markers close to the genes for glucokinase, hexokinase II, adenosine deaminase, pituitary adenylate cyclase-activating polypeptide receptor, and glucagon-like peptide-1 receptor. Linkage analysis with diabetes gave cumulative log of the odds (LOD) scores of less than -3, implying that mutations in these genes are unlikely to provide a major genetic contribution to this form of MODY.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Q J Med. 1974 Apr;43(170):339-57 - PubMed
    1. Diabetes. 1993 Jan;42(1):106-12 - PubMed
    1. Diabetologia. 1987 Oct;30(10):763-8 - PubMed
    1. Biochem J. 1993 Nov 1;295 ( Pt 3):673-7 - PubMed
    1. Diabet Med. 1988 Jul-Aug;5(5):444-8 - PubMed

Publication types

MeSH terms

LinkOut - more resources

  NODES
twitter 2