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. 1996 Feb 15;379(6566):606-12.
doi: 10.1038/379606a0.

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

B Giros  1 , M Jaber, S R Jones, R M Wightman, M G Caron
Affiliations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

B Giros et al. Nature. .

Abstract

Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels. In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission. The dopamine transporter is an obligatory _target of cocaine and amphetamine, as these psychostimulants have no effect on locomotor activity or dopamine release and uptake in mice lacking the transporter.

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