doi: 10.1038/382319a0.
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
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- PMID: 8684459
- DOI: 10.1038/382319a0
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A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
Nature.
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Abstract
The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase.
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