Signal transduction through lipid second messengers
- PMID: 8791422
- DOI: 10.1016/s0955-0674(96)80061-5
Signal transduction through lipid second messengers
Abstract
This review emphasizes the generation of glycerolipid and sphingolipid second messengers, and their molecular _targets. The role of the phosphatidylinositol transfer protein and phospholipase D in signal transmission, and the structures of the 1, 2-diacylglycerol and calcium-binding sites of protein kinase C are discussed. Further, ceramide signaling through protein kinases and the role of cross-talk in the signaling of apoptosis and inflammation are addressed.
Similar articles
-
Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling.FASEB J. 1997 Jan;11(1):45-50. doi: 10.1096/fasebj.11.1.9034165. FASEB J. 1997. PMID: 9034165 Review.
-
Sphingoid bases and phospholipase D activation.Chem Phys Lipids. 1996 May 24;80(1-2):27-36. doi: 10.1016/0009-3084(96)02543-1. Chem Phys Lipids. 1996. PMID: 8681426 Review.
-
Lipid second messenger regulation: the role of diacylglycerol kinases and their relevance to hypertension.J Hum Hypertens. 2001 Feb;15(2):93-8. doi: 10.1038/sj.jhh.1001139. J Hum Hypertens. 2001. PMID: 11317187 Review.
-
Lipid second messengers derived from glycerolipids and sphingolipids, and their role in smooth muscle function.Acta Physiol Scand. 1998 Dec;164(4):533-48. doi: 10.1111/j.1365-201x.1998.tb10703.x. Acta Physiol Scand. 1998. PMID: 9887976 Review.
-
[Sphingolipid-mediated apoptotic signaling pathways].J Soc Biol. 2003;197(3):217-21. J Soc Biol. 2003. PMID: 14708343 Review. French.
Cited by
-
Sphingolipid signaling in metabolic disorders.Cell Metab. 2012 Oct 3;16(4):420-34. doi: 10.1016/j.cmet.2012.06.017. Epub 2012 Sep 13. Cell Metab. 2012. PMID: 22982021 Free PMC article. Review.
-
Effect of Di-(2-ethylhexyl)-phthalate on Sphingolipid Metabolic Enzymes in Rat Liver.Toxicol Res. 2011 Sep;27(3):185-90. doi: 10.5487/TR.2011.27.3.185. Toxicol Res. 2011. PMID: 24278571 Free PMC article.
-
Regulation of cellular diacylglycerol through lipid phosphate phosphatases is required for pathogenesis of the rice blast fungus, Magnaporthe oryzae.PLoS One. 2014 Jun 24;9(6):e100726. doi: 10.1371/journal.pone.0100726. eCollection 2014. PLoS One. 2014. PMID: 24959955 Free PMC article.
-
A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction.J Exp Med. 1999 May 17;189(10):1581-9. doi: 10.1084/jem.189.10.1581. J Exp Med. 1999. PMID: 10330437 Free PMC article.
-
Stereoselective synthesis and transformation of pinane-based 2-amino-1,3-diols.Beilstein J Org Chem. 2021 May 3;17:983-990. doi: 10.3762/bjoc.17.80. eCollection 2021. Beilstein J Org Chem. 2021. PMID: 34025806 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources