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Review
. 1996 Apr;8(2):159-67.
doi: 10.1016/s0955-0674(96)80061-5.

Signal transduction through lipid second messengers

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Free article
Review

Signal transduction through lipid second messengers

S Spiegel et al. Curr Opin Cell Biol. 1996 Apr.
Free article

Abstract

This review emphasizes the generation of glycerolipid and sphingolipid second messengers, and their molecular _targets. The role of the phosphatidylinositol transfer protein and phospholipase D in signal transmission, and the structures of the 1, 2-diacylglycerol and calcium-binding sites of protein kinase C are discussed. Further, ceramide signaling through protein kinases and the role of cross-talk in the signaling of apoptosis and inflammation are addressed.

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