Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Oct 1;24(19):3739-47.
doi: 10.1093/nar/24.19.3739.

p72: a human nuclear DEAD box protein highly related to p68

G M Lamm  1 , S M Nicol, F V Fuller-Pace, A I Lamond
Affiliations

p72: a human nuclear DEAD box protein highly related to p68

G M Lamm et al. Nucleic Acids Res. .

Abstract

P72, a novel human member of the DEAD box family of putative RNA-dependent ATPases and ATP-dependent RNA helicases was isolated from a HeLa cDNA library. The predicted amino acid sequence of p72 is highly homologous to that of the prototypic DEAD box protein p68. In addition to the conserved core domains characteristic of DEAD box proteins, p72 contains several N-terminal RGG RNA-binding domains and a serine/glycine rich C-terminus likely involved in mediating protein-protein interactions. A p72-specific probe detects two mRNAs of approximately 5300 and 9300 bases which, although ubiquitously expressed, show variability in their expression levels in different tissues. Purified recombinant p72 exhibits ATPase activity in the presence of a range of RNA moieties. Immunocytochemical studies of p68 and p72 show that these proteins localise to similar locations in the nucleus of HeLa cells, suggesting their involvement in a nuclear process.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Genes Dev. 1991 Dec;5(12A):2212-24 - PubMed
    1. Annu Rev Biochem. 1992;61:419-40 - PubMed
    1. Nature. 1983 Apr 28;302(5911):794-800 - PubMed
    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Nature. 1989 Jan 12;337(6203):121-2 - PubMed

Publication types

Associated data

  NODES
twitter 2