Herpes simplex virus latent infection in the nervous system
- PMID: 9222339
- DOI: 10.3109/13550289509111007
Herpes simplex virus latent infection in the nervous system
Abstract
Herpes simplex virus (HSV) establishes a latent infection in the human peripheral nervous system and can cause recurrent disease by reactivation. Intensive effort has been directed in recent years to unveil the molecular, cellular and immune mechanisms, as well as the virus-host interactions associated with latent HSV infection. The aim of this review is to summarize current knowledge regarding the site of latent infection, the molecular phenomena of latency, and the mechanisms of the various stages of HSV-1 latent infection in the nervous system, relating them where possible to the human situation. Specifically, the following biological questions are addressed: (1) How does this lytic virus survive in the nervous system and why can it establish a lifelong latent infection in nerve cells? (2) What advantage is conferred on HSV by establishing latent infection in nervous tissue? (3) What can be gathered from the accumulated knowledge on latency about the pathogenesis of herpes simplex encephalitis?
Similar articles
-
Herpes simplex virus latency.Expert Rev Mol Med. 2003 Dec 5;5(29):1-14. doi: 10.1017/S1462399403006975. Expert Rev Mol Med. 2003. PMID: 14987404 Review.
-
Defining nervous system susceptibility during acute and latent herpes simplex virus-1 infection.J Neuroimmunol. 2017 Jul 15;308:43-49. doi: 10.1016/j.jneuroim.2017.02.020. Epub 2017 Mar 8. J Neuroimmunol. 2017. PMID: 28302316 Free PMC article. Review.
-
Herpes simplex virus type 1 gene expression and reactivation of latent infection in the central nervous system.Neuropathol Appl Neurobiol. 1994 Jun;20(3):253-60. doi: 10.1111/j.1365-2990.1994.tb00967.x. Neuropathol Appl Neurobiol. 1994. PMID: 7936075
-
A dual fluorescent herpes simplex virus type 1 recombinant reveals divergent outcomes of neuronal infection.J Virol. 2024 May 14;98(5):e0003224. doi: 10.1128/jvi.00032-24. Epub 2024 Apr 23. J Virol. 2024. PMID: 38651900 Free PMC article.
-
The latency-associated gene of herpes simplex virus type 1 (HSV-1) interferes with superinfection by HSV-1.J Neurovirol. 2002 Dec;8 Suppl 2:97-102. doi: 10.1080/13550280290167920. J Neurovirol. 2002. PMID: 12491159 Review.
Cited by
-
Differential Involvement during Latent Herpes Simplex Virus 1 Infection of the Superior and Inferior Divisions of the Vestibular Ganglia: Implications for Vestibular Neuritis.J Virol. 2017 Jun 26;91(14):e00331-17. doi: 10.1128/JVI.00331-17. Print 2017 Jul 15. J Virol. 2017. PMID: 28446678 Free PMC article.
-
Characterization of neuronal populations in the human trigeminal ganglion and their association with latent herpes simplex virus-1 infection.PLoS One. 2013 Dec 19;8(12):e83603. doi: 10.1371/journal.pone.0083603. eCollection 2013. PLoS One. 2013. PMID: 24367603 Free PMC article.
-
Strategies for the rapid construction of conditionally-replicating HSV-1 vectors expressing foreign genes as anticancer therapeutic agents.Mol Pharm. 2011 Feb 7;8(1):44-9. doi: 10.1021/mp100230y. Epub 2010 Dec 17. Mol Pharm. 2011. PMID: 21142023 Free PMC article. Review.
-
Involvement of apolipoprotein E in the hematogenous route of herpes simplex virus type 1 to the central nervous system.J Virol. 2002 Dec;76(23):12394-8. doi: 10.1128/jvi.76.23.12394-12398.2002. J Virol. 2002. PMID: 12414984 Free PMC article.
-
Transgenic mouse with the herpes simplex virus type 1 latency-associated gene: expression and function of the transgene.J Virol. 2003 Dec;77(23):12421-9. doi: 10.1128/jvi.77.23.12421-12429.2003. J Virol. 2003. PMID: 14610166 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Other Literature Sources
Medical