doi: 10.1016/s0014-5793(97)01480-4.
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
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- PMID: 9450543
- DOI: 10.1016/s0014-5793(97)01480-4
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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
FEBS Lett.
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Free article
Abstract
The tumor suppressor p53 is degraded by the ubiquitin-proteasome system. p53 was polyubiquitinated in the presence of E1, UbcH5 as E2 and MDM2 oncoprotein. A ubiquitin molecule bound MDM2 through sulfhydroxy bond which is characteristic of ubiquitin ligase (E3)-ubiquitin binding. The cysteine residue in the carboxyl terminus of MDM2 was essential for the activity. These data suggest that the MDM2 protein, which is induced by p53, functions as a ubiquitin ligase, E3, in human papillomavirus-uninfected cells which do not have E6 protein.
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