Expression of intercellular adhesion molecule-1 in invasive breast cancer reflects low growth potential, negative lymph node involvement, and good prognosis
- PMID: 9516949
Expression of intercellular adhesion molecule-1 in invasive breast cancer reflects low growth potential, negative lymph node involvement, and good prognosis
Abstract
To understand the role of intercellular adhesion molecule-1 (ICAM-1) in tumor progression in the host, we examined ICAM-1 expression in breast cancer by immunohistochemistry. This study included 274 female patients with invasive breast cancer, with a median follow-up of 98 months. The molecule was identified in formalin-fixed, paraffin-embedded primary tumors, and the relationship to clinicopathological factors and prognosis was analyzed. ICAM-1 expression occurred in 50.3% of patients. ICAM-1 expression had negative correlation to tumor size (P = 0.003), lymph node metastasis (P < 0.0001), tumor infiltration (P = 0.003), nuclear pleomorphism (P = 0.004), and nuclear grade (P = 0.042). Patients with ICAM-1-positive tumors had better relapse-free and overall survival than those with negative tumors (P < 0.0001 and P = 0.0003, respectively). These results suggest that expression of ICAM-1 on cancer cells might have a role as a suppressor of tumor progression under the host immune surveillance system.
Similar articles
-
Expression of intercellular adhesion molecule-1 and prognosis in colorectal cancer.Oncol Rep. 2002 May-Jun;9(3):511-4. Oncol Rep. 2002. PMID: 11956618
-
LEA-135 expression: its association with a lower risk of recurrence and increased overall survival of patients with lymph node-positive primary invasive breast cancer.Anticancer Res. 2004 Jul-Aug;24(4):2391-400. Anticancer Res. 2004. PMID: 15330189
-
Treatment results and prognostic factors of early breast cancer treated with a breast conserving operation and radiotherapy.Jpn J Clin Oncol. 2005 Mar;35(3):126-33. doi: 10.1093/jjco/hyi039. Jpn J Clin Oncol. 2005. PMID: 15741302
-
Correlation between genetic and biological aspects in primary non-metastatic breast cancers and corresponding synchronous axillary lymph node metastasis.Breast Cancer Res Treat. 2007 Mar;101(3):279-84. doi: 10.1007/s10549-006-9300-2. Epub 2006 Jul 12. Breast Cancer Res Treat. 2007. PMID: 16835704
-
Correlation of tumor size and axillary lymph node involvement with prognosis in patients with T1 breast carcinoma.Cancer. 1998 Dec 15;83(12):2502-8. Cancer. 1998. PMID: 9874455 Review.
Cited by
-
Associations between circulating proteins and risk of breast cancer by intrinsic subtypes: a Mendelian randomisation analysis.Br J Cancer. 2022 Nov;127(8):1507-1514. doi: 10.1038/s41416-022-01923-2. Epub 2022 Jul 26. Br J Cancer. 2022. PMID: 35882941 Free PMC article.
-
Differentiation induction of human breast cancer cells by arsenite in combination with tetrandrine.Am J Transl Res. 2019 Dec 15;11(12):7310-7323. eCollection 2019. Am J Transl Res. 2019. PMID: 31934280 Free PMC article.
-
Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment.Front Immunol. 2019 May 22;10:1078. doi: 10.3389/fimmu.2019.01078. eCollection 2019. Front Immunol. 2019. PMID: 31231358 Free PMC article. Review.
-
Using a cell line breast cancer progression system to identify biomarker candidates.J Proteomics. 2014 Jan 16;96:173-83. doi: 10.1016/j.jprot.2013.11.006. Epub 2013 Nov 18. J Proteomics. 2014. PMID: 24262153 Free PMC article.
-
Association of intercellular adhesion molecule-1 single nucleotide polymorphisms with hepatocellular carcinoma susceptibility and clinicopathologic development.Tumour Biol. 2016 Feb;37(2):2067-74. doi: 10.1007/s13277-015-3992-z. Epub 2015 Sep 5. Tumour Biol. 2016. PMID: 26341495
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical
Miscellaneous