Review
doi: 10.1126/science.281.5381.1312.
Caspases: enemies within
Affiliations
- PMID: 9721091
- DOI: 10.1126/science.281.5381.1312
Item in Clipboard
Review
Caspases: enemies within
Science.
.
Abstract
Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.
Similar articles
-
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.EMBO J. 1998 Apr 15;17(8):2215-23. doi: 10.1093/emboj/17.8.2215. EMBO J. 1998. PMID: 9545235 Free PMC article.
-
ICE-like proteases and cell death.Behring Inst Mitt. 1996 Oct;(97):127-43. Behring Inst Mitt. 1996. PMID: 8950471 Review. No abstract available.
-
Caspases: key mediators of apoptosis.Chem Biol. 1998 May;5(5):R97-103. doi: 10.1016/s1074-5521(98)90615-9. Chem Biol. 1998. PMID: 9578633 Review.
-
Death by dozens of cuts.Science. 1998 Apr 3;280(5360):32-4. doi: 10.1126/science.280.5360.32. Science. 1998. PMID: 9556450 No abstract available.
-
Artificial death switches: induction of apoptosis by chemically induced caspase multimerization.Proc Natl Acad Sci U S A. 1998 May 12;95(10):5421-2. doi: 10.1073/pnas.95.10.5421. Proc Natl Acad Sci U S A. 1998. PMID: 9576895 Free PMC article. No abstract available.
Cited by
-
Dichloromethane fractions of Scrophularia oxysepala extract induce apoptosis in MCF-7 human breast cancer cells.Bosn J Basic Med Sci. 2015 Jan 29;15(1):26-32. doi: 10.17305/bjbms.2015.1.226. Bosn J Basic Med Sci. 2015. PMID: 25725141 Free PMC article.
-
Label-free quantitative proteomics reveals differentially regulated proteins in the latex of sticky diseased Carica papaya L. plants.J Proteomics. 2012 Jun 18;75(11):3191-8. doi: 10.1016/j.jprot.2012.03.021. Epub 2012 Mar 24. J Proteomics. 2012. PMID: 22465191 Free PMC article.
-
Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS.Front Chem. 2021 Mar 16;9:522708. doi: 10.3389/fchem.2021.522708. eCollection 2021. Front Chem. 2021. PMID: 33796503 Free PMC article.
-
Cleavage entropy as quantitative measure of protease specificity.PLoS Comput Biol. 2013 Apr;9(4):e1003007. doi: 10.1371/journal.pcbi.1003007. Epub 2013 Apr 18. PLoS Comput Biol. 2013. PMID: 23637583 Free PMC article.
-
The Role of p53 in Marijuana Smoke Condensates-induced Genotoxicity and Apoptosis.Environ Health Toxicol. 2012;27:e2012017. doi: 10.5620/eht.2012.27.e2012017. Epub 2012 Sep 30. Environ Health Toxicol. 2012. PMID: 23106039 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
