Review
doi: 10.1126/science.281.5381.1312.
Caspases: enemies within
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- PMID: 9721091
- DOI: 10.1126/science.281.5381.1312
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Review
Caspases: enemies within
Science.
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Abstract
Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.
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