Assessment of Cryptosporidium parvum infection in immunocompetent and immunocompromised mice and its role in triggering intestinal dysplasia

Abdou, Asmaa Gaber; Harba, Nancy M.; Afifi, Amira F.; Elnaidany, Nada Farag

doi:10.1016/j.ijid.2012.11.023

Cited by 64 publications

(83 citation statements)

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“…The mechanisms of action to promote malignancy from a parasitic infection reported here include chronic inflammation, genomic instability, activation of invasion, angiogenesis and metastasis, dysregulation of tumor suppressor genes, alteration of Wnt pathway, sustained cell proliferation, inhibition of apoptosis, modulation of energetic metabolism and evasion of immune response . Based on our results, it seems that carcinogenesis associated with parasite infections can be triggered by various mechanisms different from that the so‐called “chronic inflammatory infection process” (Table ).…”

Section: Discussionmentioning

confidence: 60%

“…Inflammation drives reactive oxygen species (ROS) generation that promotes the acquisition of mutations. This has been described in chronic infections by T. muris, P. fastosum, C. parvum, T. gondii, T. vaginalis, F. gigantica and S stercoralis . In vitro, chronic T. muris infection initiated the tumor development and increased the number of tumors in two cancer‐model mice suggesting that T. muris is associated with exacerbated intestinal tumors .…”

Section: Resultsmentioning

confidence: 76%

“…S. stercoralis eggs and adult worms were found into the moderately differentiated gastric adenocarcinoma and colon adenocarcinoma of two human cases, but causality cannot be determined . A significant correlation was found between the number of endogenous developmental stages of C. parvum and the development of high‐grade intestinal dysplasia, thus demonstrating the impact of parasite load on neoplastic transformation . Another study described the presence of carcinoma lesions, dysplastic changes in the gut of mice, associated with cryptosporidiosis .…”

Section: Resultsmentioning

confidence: 99%

“…This has been described in chronic infections by T. muris, P. fastosum, C. parvum, T. gondii, T. vaginalis, F. gigantica and S stercoralis. [9][10][11][12][13][14][15][16][17] In vitro, chronic T. muris infection initiated the tumor development and increased the number of tumors in two cancer-model mice suggesting that T. muris is associated What's new? Certain parasites may do more than cause chronic health problems.…”

Section: Chronic Inflammationmentioning

confidence: 99%

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Carcinogenesis associated with parasites other than Schistosoma, Opisthorchis and Clonorchis: A systematic review

Machicado

Marcos

2016

Intl Journal of Cancer

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Only three helminths (Schistosoma haematobium, Opisthorchis viverrini and Clonorchis sinensis) are directly associated with carcinogenesis in humans whereas the role of other parasites in cancer remains unclear. This study aimed to perform a systematic review to identify recent insights in the role of other parasite infections in carcinogenesis. We conducted systematic searches of MEDLINE and EMBASE on July 2015. Our primary outcome was the association between parasitic infections and carcinogenesis. Out of 1,266 studies, 19 were selected for detailed evaluation (eight for helminths and 11 for protozoa). The mechanisms of helminth-induced cancer included chronic inflammation, sustained proliferation, modulation of the host immune system, reprogramming of glucose metabolism and redox signaling, induction of genomic instability and destabilization of suppressor tumor proteins, stimulation of angiogenesis, resisting cell death, and activation of invasion and metastasis. In addition to the current knowledge, the following parasites were found in cancers or tumors: Echinococcus, Strongyloides, Fasciola, Heterakis, Platynosomum and Trichuris. Additional parasites were found in this systematic review that could potentially be associated with cancers or tumors but further evidence is needed to elaborate a cause-effect relationship.

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Section: Discussionmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 76%

Section: Resultsmentioning

confidence: 99%

Section: Chronic Inflammationmentioning

confidence: 99%

See 2 more Smart Citations

Carcinogenesis associated with parasites other than Schistosoma, Opisthorchis and Clonorchis: A systematic review

Machicado

Marcos

2016

Intl Journal of Cancer

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show abstract

“…Moreover dysplastic changes in the liver after C. parvum infection have been reported in SCID mice [30]. According to Abdou et al [31], only one experimental immunosuppressed mouse was demonstrating large cell dysplasia in the liver. Treated groups with miltefosine showed the improvement of liver cell architecture.…”

Section: Discussionmentioning

confidence: 99%