Mechanistic links between aging and lung fibrosis

Thannickal, Victor J.

doi:10.1007/s10522-013-9451-6

Cited by 100 publications

(86 citation statements)

References 78 publications

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“…The biological mechanisms that account for IPF as an age-related disease are not well understood. Several of the recently proposed hallmarks of aging have been linked to the pathogenesis of IPF (35,36). The switch from regeneration to fibrosis as the primary repair response may represent slow, stochastic changes in cells and/or tissues driven by the accumulation of cellular or molecular damage, as suggested by Kirkwood's disposable soma theory of aging (37).…”

Section: Role Of Infectious or Noninfectious Antigensmentioning

confidence: 99%

Fibrosis: ultimate and proximate causes

Thannickal¹,

Zhou²,

Gaggar³

et al. 2014

J. Clin. Invest.

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209

165

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Section: Role Of Infectious or Noninfectious Antigensmentioning

confidence: 99%

Fibrosis: ultimate and proximate causes

Thannickal¹,

Zhou²,

Gaggar³

et al. 2014

J. Clin. Invest.

Self Cite

209

165

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“…102 Although pathological fibrosis can occur regardless of age, aging is known as one of the major risk factors in its development. 104 The mechanism of age-associated fibrotic response is uncertain and could be attributed to genomic instability, telomere shortening, epigenetic changes, reduced autophagy, and mitochondrial dysfunction. 104 Oxidative stress is known to be associated with age-related diseases, such as idiopathic pulmonary fibrosis (IPF).…”

Section: Fibrosis As a Disease Of Agingmentioning

confidence: 99%

“…104 The mechanism of age-associated fibrotic response is uncertain and could be attributed to genomic instability, telomere shortening, epigenetic changes, reduced autophagy, and mitochondrial dysfunction. 104 Oxidative stress is known to be associated with age-related diseases, such as idiopathic pulmonary fibrosis (IPF). 103 IPF affects approximately five million people worldwide, with 200,000 in the United States.…”

Section: Fibrosis As a Disease Of Agingmentioning

confidence: 99%

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Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis

Swamy

Rajasekaran

Thannickal

2016

The American Journal of Pathology

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Aging and age-related diseases have been associated with elevated oxidative stress, which may be related to increased production of reactive species and/or a deficiency in antioxidant defenses. The nuclear factor-erythroid-2erelated factor 2 (Nrf2)-mediated antioxidant response pathway maintains cellular reduction-oxidation homeostasis by inducing the transcription of an array of cytoprotective genes. However, there is evidence of impaired Nrf2 response in aging contributing to age-related fibrotic diseases. Herein, we review mechanisms for the dysregulation of Nrf2 signaling in aging. This understanding will pave the way for the design of novel therapeutic strategies that restore Nrf2 signaling to reestablish cellular homeostasis in aging and age-related fibrotic diseases.

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“…Further, the survival rate for IPF patients markedly decreases with age (11). Although the roles of specific aging hallmarks in the pathogenesis of IPF have not been fully elucidated, numerous studies implicate agerelated alterations in cellular function in the pathogenesis of IPF (15,16).…”

mentioning

confidence: 99%