2016
DOI: 10.1186/s40169-016-0108-3
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Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint?

Abstract: Longevity and accumulation of multiple context‐dependent signaling pathways of long‐standing inflammation (antigen‐load or oxidative stress) are the results of decreased/altered regulation of immunity and loss of control switch mechanisms that we defined as Yin and Yang of acute inflammation or immune surveillance. Chronic inflammation is initiated by immune disruptors‐induced progressive changes in physiology and function of susceptible host tissues that lead to increased immune suppression and multistep dise… Show more

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Cited by 16 publications
(177 citation statements)
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“…Altering hazard/benefit ratios of microbiota are important contributing factors in 'antigen overload' for immunity and cross reactivity of antibodies against antiviral immune complexes and induction of age-like chronic diseases in younger adults. Our observations that newborn guinea pigs born from sensitized parents showed strong allergic reactions upon 1st or 2nd challenge with antigen, suggesting genetic predisposition of fetus [1,4,5] are indirectly supported by clinical data [1,18,19].…”
Section: Safety Concerns and Hidden Agenda For Publicizing Hpv Vaccinsupporting
confidence: 57%
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“…Altering hazard/benefit ratios of microbiota are important contributing factors in 'antigen overload' for immunity and cross reactivity of antibodies against antiviral immune complexes and induction of age-like chronic diseases in younger adults. Our observations that newborn guinea pigs born from sensitized parents showed strong allergic reactions upon 1st or 2nd challenge with antigen, suggesting genetic predisposition of fetus [1,4,5] are indirectly supported by clinical data [1,18,19].…”
Section: Safety Concerns and Hidden Agenda For Publicizing Hpv Vaccinsupporting
confidence: 57%
“…The genomic structures of HPVs in vaccines (e.g., inactivated high potency particles) could disturb host tissues in a variety of mechanisms (e.g., mutations of DNA components or integration into host chromosomes and instability of genomic substructures). Exposure to viral particles and adjuvant (aluminum) in vaccines, along with routine exposures to other immune disruptors are 'antigen overload' for immune system that could shift the induction of chronic health problems (e.g., increased asthma, ocular or skin allergies, hot flashes, gastrointestinal conditions or neurological and autoimmune diseases) that are features of aging to younger individuals [1,18,19]. Professionals and policy makers in other countries started raising serious questions about the "scientific uncertainties related to the safety of HPV vaccines… Sloppy science, combined with unprofessional and unfair criticism of independent research, such as the one the EMA raised against the diligent Danish researchers, is a serious threat to scientific progress and public health…".…”
Section: Safety Concerns and Hidden Agenda For Publicizing Hpv Vaccinmentioning
confidence: 99%
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