Adipose-Derived Mesenchymal Stem Cells Reduce Lymphocytic Infiltration in a Rabbit Model of Induced Autoimmune Dacryoadenitis

Li, Xue; Lu, Xiaoxiao; Sun, Deming; Wang, Xilian; Yang, Lu; Nian, Hong; Wei, Ruihua

doi:10.1167/iovs.15-17824

Cited by 27 publications

(22 citation statements)

References 52 publications

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“…LG dysfunction is mainly due to the infiltration of immune cells [75]. Our research team has verified that MSC administration efficiently alleviated induced autoimmune dacryoadenitis in rabbit models, which closely mimic human SS [76]. It is noted that MSC-Exos mediate the immunosuppressive effects of their parent cells and are deemed as promising surrogates for MSC-based therapy [33].…”

Section: Exosomes In Immune-mediated Eye Diseasesmentioning

confidence: 80%

Recent advances of exosomes in immune-mediated eye diseases

Zhao

Wei

et al. 2019

Stem Cell Res Ther

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Exosomes, nanosized extracellular vesicles of 30–150 nm, are shed by almost all cell types. Bearing proteins, lipids, RNAs, and DNAs, exosomes have emerged as vital biological mediators in cell-to-cell communication, affecting a plethora of physiological and pathological processes. Particularly, mounting evidence indicates that immunologically active exosomes can regulate both innate and adaptive immune responses. Herein, we review recent advances in the research of exosomes in several immune-mediated eye diseases, including Sjögren’s syndrome (SS) dry eye, corneal allograft rejection, autoimmune uveitis, and age-related macular degeneration (AMD). Additionally, we discuss the potential of exosomes as novel biomarkers and drug delivery vesicles for the diagnosis and treatment of eye diseases.

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Section: Exosomes In Immune-mediated Eye Diseasesmentioning

confidence: 80%

Recent advances of exosomes in immune-mediated eye diseases

Zhao

Wei

et al. 2019

Stem Cell Res Ther

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“…All rabbits were subjected to a standardized ocular examination before the experimentation, and those with any pre-existing eye defects were excluded. Autoimmune dacryoadenitis was induced as introduced previously [18]. Briefly, the left inferior…”

Section: Rabbit Autoimmune Dacryoadenitis Modelmentioning

confidence: 99%

“…Clinical assessments including tear production, tear break-up time (BUT) and cornea fluorescein staining were performed every two weeks after injection of activated PBLs. Specific inspection method and scoring criteria were the same as those described previously [18]. Rabbits were sacrificed at 6w and the right inferior LGs were dissected out for the histologic analysis.…”

Section: Clinical and Histopathological Assessmentmentioning

confidence: 99%

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MicroRNA expression profile of Lacrimal Glands in rabbit autoimmune dacryoadenitis model

et al. 2020

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Purpose: To identify the differential expression of microRNAs (miRs) and the related gene networks and signal pathways in lacrimal glands (LGs) of rabbit autoimmune dacryoadenitis. Methods: Autoimmune dacryoadenitis in rabbits was induced by transferring activated peripheral blood lymphocytes (PBLs). The LGs of normal and model group rabbits were collected for small RNA sequencing. The most differentially expressed miRs were validated by quantitative real time-polymerase chain reaction (qRT-PCR). Further, bioinformatics analysis including _target gene prediction, Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Results: A total of 15 miRs were differentially expressed in the LGs of rabbit autoimmune dacryoadenitis relative to normal controls. GO and KEGG analysis revealed that most _target genes of these dysregulated miRs were implicated in MAPK signaling pathway. Conclusion: Our results showed for the first time the differentially expressed miRs and the related pathways involved in the pathogenesis of rabbit autoimmune dacryoadenitis. These results may contribute to elucidating molecular pathogenesis of Sjögren's syndrome (SS) dry eye.

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“…We read with great interest the recently published article by Xue Li and colleagues 1 that investigated the immunoregulatory roles of adipose-derived mesenchymal stem cells (ADSCs) in a rabbit model of induced autoimmune dacryoadenitis. In their study, the authors performed much research and demonstrated that allogeneic ADSCs are effective for treating autoimmune dacryoadenitis in rabbits 1 ; however, we believe that some results and conclusions presented in their article deserve further discussion.…”

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confidence: 95%