Joint impact of gestational diabetes and obesity on perinatal outcomes

Huet, Justin; Beucher, G.; Rod, A.; Morello, Rémy; Dreyfus, Michel

doi:10.1016/j.jogoh.2018.08.003

Cited by 30 publications

(54 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Obesity and GD can lead to adverse outcomes, and, in our study, women who were overweight and obese prior to gestation had an increased risk of adverse pregnancy outcomes. Similar to reports in the literature, in our study, women who were overweight or obese were more often diagnosed with gestational hypertension or preeclampsia (11,15,20,21,23,24), labor was more likely to be induced (20), and the rate of cesarean section was higher (9,15,20,24,25). The risk of developing gestational hypertension was significantly higher in overweight and obese women.…”

Section: Discussionsupporting

confidence: 88%

“…In this study, there was a progressive increase in OR with the increasing BMI category regarding cesarean section. In some studies, the cesarean delivery rate reported in obese women with GD was approximately 40.0% (6,15,20), with one study reporting a 72.7% rate with a 3.2-fold increased risk of cesarean section (OR 3.26; IC 95% 1.57-6.76, p = 0.002) (24). The high percentage of cesarean delivery in this population could be due to suspected macrosomia or failure to induce labor.…”

Section: Discussionmentioning

confidence: 83%

“…Moreover, the combination of GD and obesity is associated with more adverse pregnancy outcomes compared to GD or obesity alone (10). Recently, a study showed that women with GD and obesity had an increased risk of cesarean section, preeclampsia, and maternal morbidity when compared to either non-obese patients with GD and obese patients without GD (15).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of overweight and obesity on pregnancy outcomes in women with gestational diabetes – results from a retrospective multicenter study

Machado

Monteiro

Oliveira

2019

Archives of Endocrinology and Metabolism

View full text Add to dashboard Cite

Objective: The aim of this study was to evaluate the impact of pre-pregnancy body mass index (BMI) on pregnancy outcomes in women with gestational diabetes (GD). Subjects and methods: Retrospective multicenter study using data from the Portuguese National Register. We included women with GD with a singleton pregnancy. GD diagnosis was according to the International Association of the Diabetes and Pregnancy Study Group criteria. Women were divided into groups according to their pre-pregnancy BMI: < 18.5 kg/m 2 (underweight), ≥ 18.5 and < 25.0 kg/m 2 (normal weight), ≥ 25 and < 30 kg/m 2 (overweight) and ≥ 30 kg/m 2 (obese). Results: We included 3,103 pregnant women with GD, 29.6% (n = 918) were overweight and 27.3% (n = 846) were obese. Compared to normal weight, the overweight and obese groups had a higher percentage of gestational hypertension (4.0% and 8.5% vs. 2.1%), cesarean delivery (32.8% and 41.3% vs. 27.9%), macrosomia (3.9% and 6.7% vs. 2.4%), and large for gestational age (LGA) newborns (8.3% and 13.5% vs. 6.0%). Obesity increased the risk of gestational hypertension (OR 4.5, p < 0.001), preeclampsia (OR 1.9, p = 0.034), cesarean delivery (OR 2.0, p < 0.001), macrosomia (OR 3.1, p < 0.001) and LGA (OR 2.3, p < 0.001). Conclusion: In pregnant women with GD, pregnancy complications increase with pre-pregnancy BMI. In obese women, appropriate diet and counseling prior to gestation and more aggressive medical intervention during pregnancy are needed in order to prevent macrosomic and LGA newborns and to reduce maternal complications.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of overweight and obesity on pregnancy outcomes in women with gestational diabetes – results from a retrospective multicenter study

Machado

Monteiro

Oliveira

2019

Archives of Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…За формирование макросомии при ДФ отвечают соматомедины, синтез которых повышается на фоне фетальной гиперинсулинемии и гипергликемии [3,27,29]. Развитие макросомии также связано с чрезмерной пролиферацией клеток плаценты [30].…”

Section: таблицаunclassified

“…Патогенез макросомии до конца не ясен. Известно [29], что, начиная со II триместра, на гипергликемию плод реагирует гиперплазией β-клеток и увеличением уровня инсулина (состояние гиперинсулинизма), что приводит к клеточному росту, усилению выработки белка и липогенезу. На фоне гипергликемии в печени, селезенке и фибробластах в ответ на рост уровня соматотропного гормона повышается синтез соматомединов (факторов роста), которые обусловливают формирование макросомии.…”

unclassified

Physical development of newborns born to mothers with different carbohydrate metabolism disorders

Харитонова¹,

Папышева²,

Богомаз³

et al. 2019

Eksp. Klin. Gastroenterol.

View full text Add to dashboard Cite

РезюмеВведение: ежегодно от 50 до 150 тысяч младенцев рождается от матерей с сахарным диабетом. В настоящее время нет сомнений в том, что состояние новорожденных, родившихся от матерей с сахарным диабетом требует особого внимания из-за повышенного риска развития заболеваний дыхательных путей, сердечно-сосудистой системы, головного мозга, почек, а также различных нарушений нутритивного статуса Цель: Изучить состояние физического развития и нутритивного статуса у детей, родившихся от матерей с различными нарушениями углеводного обмена Материалы и методы: 350 доношенных детей от матерей с сахарным диабетом, родившихся в родильном доме ГКБ им. Н. Э. Баумана. Оценка физического развития детей проводилась в соответствии со стандартами ВОЗ WHO Anthro (2006). Сравнительный анализ показателей детей в разных группах проводился с помощью T-критерия Стьюдента. Использовалась программа Statistica 10.Результаты: масса тела 350 обследованных новорожденных варьировала в пределах 1590-4710 г, в среднем составила 3421.1 ± 543.99 г. Было 67 (19,1%) детей с массой тела менее 3000 г и 46 (13,1%) более 4000 г. Значения роста 350 новорожденных составляли от 40 до 57 см, в среднем -51,21 ± 2,54 см. Были изучены показатели физического развития и проведен анализ во всех группах детей в зависимости от пола (массы тела (м), длины тела (Н), ИМТ; отношения массы тела к длине тела) в экспериментальной и контрольной группах.

show abstract

The relationship between body mass index and sleep in women with risk factors for gestational diabetes mellitus

Reyes

Hague

Teede

et al. 2023

Obesity Science & Practice

View full text Add to dashboard Cite

BackgroundBoth obesity and sleep disorders are common among women during pregnancy. Although prior research has identified a relationship between obesity and sleep disorders, those findings are from women later in pregnancy.ObjectiveTo explore the relationships between self‐reported sleep duration, insufficient sleep and snoring with body mass index (BMI) among multiethnic women at risk of gestational diabetes mellitus (GDM)in early pregnancy.MethodsCross‐sectional study of baseline data from women at risk of GDM enrolled in the Treatment of BOoking Gestational diabetes Mellitus (TOBOGM) multicentre trial across 12 Australian/Austrian sites. Participants completed a questionnaire before 20 weeks’ gestation to evaluate sleep. BMI <25 kg/m2 served as the reference group in multivariable logistic regression.ResultsAmong the 2865 women included, the prevalence of overweight and obesity classes I‐III was 28%, 19%, 11% and 12%, respectively. There was no relationship between sleep duration and BMI. The risk of insufficient sleep >5 days/month was higher in class II and class III obesity (1.38 (1.03–1.85) and 1.34 (1.01–1.80), respectively), and the risk of snoring increased as BMI increased (1.59 (1.25–2.02), 2.68 (2.07–3.48), 4.35 (3.21–5.88) to 4.96 (3.65–6.74), respectively)).ConclusionsObesity is associated with insufficient sleep among pregnant women at risk of GDM. Snoring is more prevalent with increasing BMI.

show abstract

Joint impact of gestational diabetes and obesity on perinatal outcomes

Cited by 30 publications

References 24 publications

Impact of overweight and obesity on pregnancy outcomes in women with gestational diabetes – results from a retrospective multicenter study

Impact of overweight and obesity on pregnancy outcomes in women with gestational diabetes – results from a retrospective multicenter study

Physical development of newborns born to mothers with different carbohydrate metabolism disorders

The relationship between body mass index and sleep in women with risk factors for gestational diabetes mellitus

Contact Info

Product

Resources

About