Analogni pirimidini
Analogni pirimidini su antimetaboliti, koji imitiraju strukturu metaboličkih pirimidina.
Primeri
uredi- 5-flourouracil[1] (5FU) koji inhibira timidilat sintazu.[2]
- Floksuridin (FUDR)
- Citozin arabinozid (Citarabin)
Reference
uredi- ↑ Huhtala A, Rönkkö S, Teräsvirta M, et al. (May 2009). „The effects of 5-fluorouracil on ocular tissues in vitro and in vivo after controlled release from a multifunctional implant”. Invest. Ophthalmol. Vis. Sci. 50 (5): 2216–23. DOI:10.1167/iovs.08-3016. PMID 19136700.
- ↑ Xi Y, Formentini A, Nakajima G, Kornmann M, Ju J (January 2008). „Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer”. Oncol. Rep. 19 (1): 257–62. PMID 18097604.