Ciklin-zavisna kinaza
Ciklin-zavisna kinaza (EC 2.7.11.22, Bur1, Bur1 Cdk, Cak1, Cak1p, cdc2, cdc2 kinaza, Cdc28p, CDK, cdk-aktivirajuća kinaza, Cdk-aktivirajuća proteinska kinaza, cdk1, cdk2, Cdk2, cdk3, cdk4, cdk5, cdk6, cdk7, cdk8, cdk9, ciklin A-aktivirajući cdc2, ciklin A-aktivirajući cdk2, ciklin D-cdk6 kinaza, ciklin D-zavisni kinaza, ciklin E kinaza, ciklin-A vezana kinaza, ciklin-zavisna kinaza 6, ciklin-zavisna kinaza-2, ciklin-zavisna kinaza-4, ciklin-zavisna protein kinaza aktivirajuća kinaza, cyk, D-tip ciklinska kinaza, nclk, neuronal cdc2-slična kinaza, PCTAIRE-1, STK25) je enzim sa sistematskim imenom ATP:ciklin fosfotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ciklin-zavisna kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.22 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + protein ADP + fosfoprotein
Za aktivaciju ciklin-zavisne kinaze neophodno je vezivanje enzima sa regulatornom podjedinicom, ciklinom.
Reference
uredi- ↑ Johnson, D.G. and Walker, C.L. (1999). „Cyclins and cell cycle checkpoints”. Annu. Rev. Pharmacol. Toxicol. 39: 295-312. PMID 10331086.
- ↑ Pan, Z.Q., Amin, A. and Hurwitz, J. (1993). „Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities”. J. Biol. Chem. 268: 20443-20451. PMID 8397207.
- ↑ Yee, A., Wu, L., Liu, L., Kobayashi, R., Xiong, Y. and Hall, F.L. (1996). „Biochemical characterization of the human cyclin-dependent protein kinase activating kinase. Identification of p35 as a novel regulatory subunit”. J. Biol. Chem. 271: 471-477. PMID 8550604.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.