Metabolomika
Metabolomika je naučna studija hemijskih procesa u kojima učestvuju metaboliti. Metabolomika je sistematsko izučavanje jedinstvenih hemijskih otisaka koji su specifčni za ćelijske procese. Ona je studija motaboličkih profila malih molekula.[1] Metabolom je kolekcija svih metabolita u biološkoj ćeliji, tkivu, organu ili organizmu, koji su krajnji produkti ćelijskih procesa.[2] Dok celokupni podaci iRNK genske ekspresije i proteomskih analiza ne sadrže potpunu informaciju o ćelijskim procesima, metabolički profil može da pruži trenutnu sliku ćelijske fiziologije. Jedan od izazova sistemske biologije i funkcionalne genomike je integracija proteomske, transkriptomske, i metabolomske informacije da bi se formirala kompletnija slika živih organizama.
Reference
uredi- ↑ Daviss, Bennett (April 2005). „Growing pains for metabolomics”. The Scientist 19 (8): 25–28.
- ↑ Jordan KW, Nordenstam J, Lauwers GY, Rothenberger DA, Alavi K, Garwood M, Cheng LL (March 2009). „Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy”. Diseases of the Colon & Rectum 52 (3): 520–5. DOI:10.1007/DCR.0b013e31819c9a2c. PMC 2720561. PMID 19333056.
Literatura
uredi- Tomita M, Nishioka T (2005). Metabolomics: The Frontier of Systems Biology. Springer. ISBN 4-431-25121-9.
- Weckwerth, Wolfram (2006). Metabolomics: Methods And Protocols (Methods in Molecular Biology). Humana Press. ISBN 1-588-29561-3. OCLC 493824826.
- Fan TW, Lorkiewicz PK, Sellers K, Moseley HN, Higashi RM, Lane AN (March 2012). „Stable isotope-resolved metabolomics and applications for drug development”. Pharmacol. Ther. 133 (3): 366–91. DOI:10.1016/j.pharmthera.2011.12.007. PMC 3471671. PMID 22212615.
- Ellis DI, Goodacre R (2006). „Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy”. Analyst 131 (8): 875–885. Bibcode 2006Ana...131..875E. DOI:10.1039/b602376m. PMID 17028718.
- Claudino WM, Quatronne A, Pestrim M, Biganzoli L, Bertini, Di Leo A (2007). „Metabolomics: Available results, current research projects in breast cancer, and future applications”. J Clin Oncol 25 (19): 2840–6. DOI:10.1200/JCO.2006.09.7550. PMID 17502626. Arhivirano iz originala na datum 2008-01-20. Pristupljeno 2014-03-17.
- Ellis DI, Dunn WB, Griffin JL, Allwood JW, Goodacre R (2007). „Metabolic fingerprinting as a diagnostic tool”. Pharmacogenomics 8 (9): 1243–1266. DOI:10.2217/14622416.8.9.1243. PMID 17924839.
- Bundy JG, Davey MP, Viant, MR (2009). „Environmental metabolomics: A critical review and future perspectives”. Metabolomics 5: 3–21. DOI:10.1007/s11306-008-0152-0.[mrtav link]
- Kenneth Haug, Reza M. Salek, Pablo Conesa, Janna Hastings, Paula de Matos, Mark Rijnbeek, Tejasvi Mahendrakar, Mark Williams, Steffen Neumann, Philippe Rocca-Serra, Eamonn Maguire, Alejandra González-Beltrán, Susanna-Assunta Sansone, Julian L. Griffin and Christoph Steinbeck. (2013). „MetaboLights-- an open-access general-purpose repository for metabolomics studies and associated meta-data.”. Nucl. Acids Res. 41 (D1): D781-D786. DOI:10.1093/nar/gks1004.
Spoljašnje veze
uredi
- Metabolism na Projektu Open Directory
- HMDB
- METLIN Arhivirano 2010-12-28 na Wayback Machine-u
- XCMS Arhivirano 2010-12-28 na Wayback Machine-u
- LCMStats
- Metabolights
- Global map of metabolomics labs