NAD(P)H dehidrogenaza (hinon)
NAD(P)H dehidrogenaza (hinon) (EC 1.6.5.2, menadionska reduktaza, filohinonska reduktaza, hinonska reduktaza, dehidrogenaza, redukovani nikotinamid adenin dinukleotid (fosfat, hinon), DT-dijaforaza, flavoprotein NAD(P)H-hinon reduktaza, menadionska oksidoreduktaza, NAD(P)H dehidrogenaza, NAD(P)H menadion reduktaza, NAD(P)H-hinon dehidrogenaza, NAD(P)H-hinon oksidoreduktaza, NAD(P)H: (hinon-akceptor)oksidoreduktaza, NAD(P)H:menadion oksidoreduktaza, NADH-menadionska reduktaza, naftohinonska reduktaza, p-benzohinonska reduktaza, redukovani NAD(P)H dehidrogenaza, vitamin K reduktaza, dijaforaza, redukovani nikotinamid-adenin dinukleotid (fosfat) dehidrogenaza, vitamin-K reduktaza, NAD(P)H2 dehidrogenaza (hinon), NQO1, QR1, NAD(P)H:(hinon-akceptor) oksidoreduktaza) je enzim sa sistematskim imenom NAD(P)H:hinon oksidoreduktaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
| NAD(P)H dehidrogenaza (hinon) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| NAD(P)H dehidrogenaza (hinon) tetramer, Brucella abortus | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.6.5.2 | ||||||||
| CAS broj | 9032-20-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- NAD(P)H + H+ + hinon NAD(P)+ + hidrohinon
Ovaj enzim je flavoprotein. On katalizuje dvoelektronsku redukciju i ima prefereniju za kratkolančane nononske akceptore, kao što su ubihinon, benzohinon, juglon i durohinon.
Reference
uredi- ↑ di Prisco, G., Casola, L. and Giuditta, A. (1967). „Purification and properties of a soluble reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase from the hepatopancreas of Octopus vulgaris”. Biochem. J. 105: 455-460. PMID 4171422.
- ↑ Giuditta, A. and Strecker, H.J. (1961). „Purification and some properties of a brain diaphorase”. Biochim. Biophys. Acta 48: 10-19. PMID 13705804.
- ↑ Märki, F. and Martius, C. (1960). „Vitamin K-Reductase, Darsellung und Eigenschaften”. Biochem. Z. 333: 111-135. PMID 13765127.
- ↑ Misaka, E. and Nakanishi, K. (1963). „Studies on menadione reductase of bakers' yeast. I. Purification, crystallization and some properties”. J. Biochem. (Tokyo) 53: 465-471.
- ↑ Wosilait, W.D. (1960). „The reduction of vitamin K1 by an enzyme from dog liver”. J. Biol. Chem. 235: 1196-1201. PMID 13846011.
- ↑ Sparla, F., Tedeschi, G. and Trost, P. (1996). „NAD(P)H:(quinone-acceptor) oxidoreductase of tobacco leaves is a flavin mononucleotide-containing flavoenzyme”. Plant Physiol. 112: 249-258. PMID 12226388.
- ↑ Braun, M., Bungert, S. and Friedrich, T. (1998). „Characterization of the overproduced NADH dehydrogenase fragment of the NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli”. Biochemistry 37: 1861-1867. PMID 9485311.
- ↑ Jaiswal, A.K. (2000). „Characterization and partial purification of microsomal NAD(P)H:quinone oxidoreductases”. Arch. Biochem. Biophys. 375: 62-68. PMID 10683249.
- ↑ Li, R., Bianchet, M.A., Talalay, P. and Amzel, L.M. (1995). „The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction”. Proc. Natl. Acad. Sci. USA 92: 8846-8850. PMID 7568029.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.