NAD(P)H dehidrogenaza (hinon)
NAD(P)H dehidrogenaza (hinon) (EC 1.6.5.2, menadionska reduktaza, filohinonska reduktaza, hinonska reduktaza, dehidrogenaza, redukovani nikotinamid adenin dinukleotid (fosfat, hinon), DT-dijaforaza, flavoprotein NAD(P)H-hinon reduktaza, menadionska oksidoreduktaza, NAD(P)H dehidrogenaza, NAD(P)H menadion reduktaza, NAD(P)H-hinon dehidrogenaza, NAD(P)H-hinon oksidoreduktaza, NAD(P)H: (hinon-akceptor)oksidoreduktaza, NAD(P)H:menadion oksidoreduktaza, NADH-menadionska reduktaza, naftohinonska reduktaza, p-benzohinonska reduktaza, redukovani NAD(P)H dehidrogenaza, vitamin K reduktaza, dijaforaza, redukovani nikotinamid-adenin dinukleotid (fosfat) dehidrogenaza, vitamin-K reduktaza, NAD(P)H2 dehidrogenaza (hinon), NQO1, QR1, NAD(P)H:(hinon-akceptor) oksidoreduktaza) je enzim sa sistematskim imenom NAD(P)H:hinon oksidoreduktaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
| NAD(P)H dehidrogenaza (hinon) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 NAD(P)H dehidrogenaza (hinon) tetramer, Brucella abortus | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.6.5.2 | ||||||||
| CAS broj | 9032-20-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- NAD(P)H + H+ + hinon NAD(P)+ + hidrohinon
Ovaj enzim je flavoprotein. On katalizuje dvoelektronsku redukciju i ima prefereniju za kratkolančane nononske akceptore, kao što su ubihinon, benzohinon, juglon i durohinon.
Reference
уреди- ^ di Prisco, G., Casola, L. and Giuditta, A. (1967). „Purification and properties of a soluble reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase from the hepatopancreas of Octopus vulgaris”. Biochem. J. 105: 455—460. PMID 4171422.
- ^ Giuditta, A. & Strecker, H.J. (1961). „Purification and some properties of a brain diaphorase”. Biochim. Biophys. Acta. 48: 10—19. PMID 13705804.
- ^ Märki, F. and Martius, C. (1960). „Vitamin K-Reductase, Darsellung und Eigenschaften”. Biochem. Z. 333: 111—135. PMID 13765127.
- ^ Misaka, E. & Nakanishi, K. (1963). „Studies on menadione reductase of bakers' yeast. I. Purification, crystallization and some properties”. J. Biochem. (Tokyo). 53: 465—471.
- ^ Wosilait, W.D. (1960). „The reduction of vitamin K1 by an enzyme from dog liver”. J. Biol. Chem. 235: 1196—1201. PMID 13846011.
- ^ Sparla, F., Tedeschi, G. and Trost, P. (1996). „NAD(P)H:(quinone-acceptor) oxidoreductase of tobacco leaves is a flavin mononucleotide-containing flavoenzyme”. Plant Physiol. 112: 249—258. PMID 12226388.
- ^ Braun, M., Bungert, S. and Friedrich, T. (1998). „Characterization of the overproduced NADH dehydrogenase fragment of the NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli”. Biochemistry. 37: 1861—1867. PMID 9485311.
- ^ Jaiswal, A.K. (2000). „Characterization and partial purification of microsomal NAD(P)H:quinone oxidoreductases”. Arch. Biochem. Biophys. 375: 62—68. PMID 10683249.
- ^ Li, R., Bianchet, M.A., Talalay, P. and Amzel, L.M. (1995). „The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction”. Proc. Natl. Acad. Sci. USA. 92: 8846—8850. PMID 7568029.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- NAD(P)H+dehydrogenase+(quinone) на US National Library of Medicine Medical Subject Headings (MeSH)
