Pregabalin

Pregabalin
IUPAC ime
	(3S)-3-(aminometil)-5-metilheksanoinska kiselina
Klinički podaci
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	6,3 sata
Izlučivanje	90% uriniom
Identifikatori
CAS broj	148553-50-8
ATC kod	N03AX16 (WHO)
PubChem	CID 5486971
DrugBank	DB00230
ChemSpider	4589156
ChEMBL	CHEMBL64356
Hemijski podaci
Formula	C8H17NO2
Molarna masa	159.2261
	SMILES CC(C)C[C@H](CN)CC(O)=O; ;
	InChI InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1 ; Key:AYXYPKUFHZROOJ-ZETCQYMHSA-N ;

Pregabalin' je antikonvulsant koji se koristi za tretiranje neuropatičkog bola, kao dodatna terapija za parcijalne konvulzije, i za generalizovani anksiozni poremećaj. Ovaj lek je razvijen da bude potentniji naslednik gabapentina. Pregabalin je u prodaji pod imenom Lyrica.^[1]^[2]^[3]^[4]^[5]

Reference

^ Drug Enforcement Administration, Department of Justice (2005). „Schedules of controlled substances: Placement of pregabalin into schedule V. Final rule”. Federal Register. 70 (144): 43633—5. PMID 16050051.
^ Su, T. Z.; Feng, M. R.; Weber, M. L. (2005). „Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells”. The Journal of Pharmacology and Experimental Therapeutics. 313 (3): 1406—15. PMID 15769862. S2CID 24993611. doi:10.1124/jpet.104.082255.
^ Li, Zheng; Taylor, Charles P.; Weber, Mark; Piechan, Julie; Prior, Faith; Bian, Feng; Cui, Mei; Hoffman, Diane; Donevan, Sean (2011). „Pregabalin is a potent and selective ligand for α2δ-1 and α2δ-2 calcium channel subunits”. European Journal of Pharmacology. 667 (1–3): 80—90. PMID 21651903. doi:10.1016/j.ejphar.2011.05.054.
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709  . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug _targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889  . PMID 18048412. doi:10.1093/nar/gkm958.

Spoljašnje veze

Pregabalin

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Drug Enforcement Administration, Department of Justice (2005). „Schedules of controlled substances: Placement of pregabalin into schedule V. Final rule”. Federal Register. 70 (144): 43633—5. PMID 16050051.

[2] Su, T. Z.; Feng, M. R.; Weber, M. L. (2005). „Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells”. The Journal of Pharmacology and Experimental Therapeutics. 313 (3): 1406—15. PMID 15769862. S2CID 24993611. doi:10.1124/jpet.104.082255.

[3] Li, Zheng; Taylor, Charles P.; Weber, Mark; Piechan, Julie; Prior, Faith; Bian, Feng; Cui, Mei; Hoffman, Diane; Donevan, Sean (2011). „Pregabalin is a potent and selective ligand for α2δ-1 and α2δ-2 calcium channel subunits”. European Journal of Pharmacology. 667 (1–3): 80—90. PMID 21651903. doi:10.1016/j.ejphar.2011.05.054.

[4] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709  . PMID 21059682. doi:10.1093/nar/gkq1126.

[5] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug _targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889  . PMID 18048412. doi:10.1093/nar/gkm958.

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