Azoospermia

Y kromozomu uzun kolu (q) distalinde sitogenetik olarak saptana-bilen delesyon bölgeleri bulunur. AZF (Azospermi Faktör) olarak adlandırılan bu delesyon bölgeleri spermatogenez ve germ hücreleri gelişim ve değişimi için gerekli olan genleri içerir. AZF lokusu spermatogenezden sorumludur. Başlangıçta 5 ve 6. bölümlerde yerleşmiş olan birbiriyle çakışmayan üç alt bölgeye ayrılan, AZFa, AZFb ve AZFc daha sonra AZFb ve AZFc arasında dördüncü bir bölge (AZFd) daha tanımlanmıştır.^[1]^[2]^[3]^[4]^[5]^[6]

Kaynakça

^ Male Infertility Best Practice Policy Committee of the American Urological Association; Practice Committee of the American Society for Reproductive Medicine (2001). Infertility: Report on Evaluation of the Azoospermic Male (PDF). American Urological Association; American Society for Reproductive Medicine. ISBN 978-0-9649702-8-1. 26 Mart 2018 tarihinde kaynağından arşivlendi (PDF). Erişim tarihi: 20 Mart 2012.
^ Jarvi, K; Lo, K; Fischer, A; Grantmyre, J; Zini, A; Chow, V; Mak, V (2010). "CUA Guideline: The workup of azoospermic males". Canadian Urological Association journal. 4 (3). ss. 163-7. PMC 2874589 $2. PMID 20514278.
^ Dohle, Gert R (2010). "Male infertility in cancer patients: Review of the literature". International Journal of Urology. 17 (4). ss. 327-331. doi:10.1111/j.1442-2042.2010.02484.x. PMID 20202000.
^ Menzies, F. M.; Shepherd, M. C.; Nibbs, R. J.; Nelson, S. M. (2010). "The role of mast cells and their mediators in reproduction, pregnancy and labour". Human Reproduction Update. 17 (3). ss. 383-396. doi:10.1093/humupd/dmq053. PMID 20959350.
^ Practice Committee of ASRM, August 2008. "The management of infertility due to obstructive azzospermia" (PDF). 4 Mart 2016 tarihinde kaynağından arşivlendi (PDF). Erişim tarihi: 14 Haziran 2010.
^ Toulis, K. A.; Iliadou, P. K.; Venetis, C. A.; Tsametis, C.; Tarlatzis, B. C.; Papadimas, I.; Goulis, D. G. (2010). "Inhibin B and anti-Mullerian hormone as markers of persistent spermatogenesis in men with non-obstructive azoospermia: a meta-analysis of diagnostic accuracy studies". Human Reproduction Update. 16 (6). ss. 713-724. doi:10.1093/humupd/dmq024. PMID 20601364.

[aua-1] Male Infertility Best Practice Policy Committee of the American Urological Association; Practice Committee of the American Society for Reproductive Medicine (2001). Infertility: Report on Evaluation of the Azoospermic Male (PDF). American Urological Association; American Society for Reproductive Medicine. ISBN 978-0-9649702-8-1. 26 Mart 2018 tarihinde kaynağından arşivlendi (PDF). Erişim tarihi: 20 Mart 2012.

[cua-2] Jarvi, K; Lo, K; Fischer, A; Grantmyre, J; Zini, A; Chow, V; Mak, V (2010). "CUA Guideline: The workup of azoospermic males". Canadian Urological Association journal. 4 (3). ss. 163-7. PMC 2874589 $2. PMID 20514278.

[dohle-3] Dohle, Gert R (2010). "Male infertility in cancer patients: Review of the literature". International Journal of Urology. 17 (4). ss. 327-331. doi:10.1111/j.1442-2042.2010.02484.x. PMID 20202000.

[Menzies2011-4] Menzies, F. M.; Shepherd, M. C.; Nibbs, R. J.; Nelson, S. M. (2010). "The role of mast cells and their mediators in reproduction, pregnancy and labour". Human Reproduction Update. 17 (3). ss. 383-396. doi:10.1093/humupd/dmq053. PMID 20959350.

[asrm-5] Practice Committee of ASRM, August 2008. "The management of infertility due to obstructive azzospermia" (PDF). 4 Mart 2016 tarihinde kaynağından arşivlendi (PDF). Erişim tarihi: 14 Haziran 2010.

[6] Toulis, K. A.; Iliadou, P. K.; Venetis, C. A.; Tsametis, C.; Tarlatzis, B. C.; Papadimas, I.; Goulis, D. G. (2010). "Inhibin B and anti-Mullerian hormone as markers of persistent spermatogenesis in men with non-obstructive azoospermia: a meta-analysis of diagnostic accuracy studies". Human Reproduction Update. 16 (6). ss. 713-724. doi:10.1093/humupd/dmq024. PMID 20601364.

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