image/svg+xml Synaptic cleft Dendrite(Postsynaptic neuron) -P DNA Long-termadaptive changes inthe brain +e -e Legend +P -P Calcium (Ca2+) ions +e Gene expression Gene repression Inhibition Neurotransmitter or ion trafficking Chronically highlevels of synaptic dopamine Glutamate(cotransmitted) NMDA receptorco-agonist Dopamine Cyclic adenosinemonophosphate DNA +P +P +P +P +P -P -P -P Phosphorylation Dephosphorylation Activation/Interaction Gene product(protein or mRNA) Complex of twogene products -e Molecule
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