Residual chloride secretion in intestinal tissue of ΔF508 homozygous twins and siblings with cystic fibrosis
I Bronsveld, F Mekus, J Bijman, M Ballmann, J Greipel… - Gastroenterology, 2000 - Elsevier
Background & Aims: Cholinergic stimulation of chloride secretion is impaired in the
intestines of patients with cystic fibrosis (CF). However, intestinal chloride secretion has
been observed in patients with mild CF mutations. The aim of this study was to investigate
residual Cl− secretion in the intestine of ΔF508 homozygous CF patients, and examine the
contribution of cystic fibrosis transmembrane conductance regulator (CFTR) and alternative
Cl− conductances. Twins and siblings with identical CFTR genotypes were investigated to …
intestines of patients with cystic fibrosis (CF). However, intestinal chloride secretion has
been observed in patients with mild CF mutations. The aim of this study was to investigate
residual Cl− secretion in the intestine of ΔF508 homozygous CF patients, and examine the
contribution of cystic fibrosis transmembrane conductance regulator (CFTR) and alternative
Cl− conductances. Twins and siblings with identical CFTR genotypes were investigated to …