Forskolin stimulates adenylate cyclase in human colonic crypts: interaction with VIP
N Boige, B Amiranoff, A Munck, M Laburthe - European journal of …, 1984 - Elsevier
Abstract Forskolin in the 10− 8− 10− 4 M concentration range (ED 50 2 μM) strongly
stimulated the cyclic AMP production of epithelial crypts isolated from the human colon. At a
maximal dose, production increased up to 500 and 700 times the basal cyclic AMP levels at
15 and 37° C, respectively. Forskolin was thus much more efficient than VIP, which is the
physiological regulator of this system. Forskolin (ED 50 7 μM) also stimulated colonic
membrane adenylate cyclase. The stimulation was immediate, did not require guanyl …
stimulated the cyclic AMP production of epithelial crypts isolated from the human colon. At a
maximal dose, production increased up to 500 and 700 times the basal cyclic AMP levels at
15 and 37° C, respectively. Forskolin was thus much more efficient than VIP, which is the
physiological regulator of this system. Forskolin (ED 50 7 μM) also stimulated colonic
membrane adenylate cyclase. The stimulation was immediate, did not require guanyl …