Aerosolized amiloride: dose effect on nasal bioelectric properties, pharmacokinetics, and effect on sputum expectoration in patients with cystic fibrosis
T HOFMANN, I SENIER, P BITTNER… - Journal of aerosol …, 1997 - liebertpub.com
Aerosolized amiloride normalizes the excessive sodium absorption across cystic fibrosis
(CF) respiratory epithelium. The aims of this study were to assess the dose-effect
relationship and the duration for which amiloride inhibits Na+ transport, to determine acute
and chronic pharmacokinetics, and to test the effect of acute aerosolized amiloride on the
amount of sputum expectorated. The effect of inhaled amiloride was assessed principally by
nasal potential difference (PD) measurements. Amiloride serum levels were measured in 23 …
(CF) respiratory epithelium. The aims of this study were to assess the dose-effect
relationship and the duration for which amiloride inhibits Na+ transport, to determine acute
and chronic pharmacokinetics, and to test the effect of acute aerosolized amiloride on the
amount of sputum expectorated. The effect of inhaled amiloride was assessed principally by
nasal potential difference (PD) measurements. Amiloride serum levels were measured in 23 …