Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice
E Hummler, P Barker, J Gatzy, F Beermann… - Nature …, 1996 - nature.com
The amiloride-sensitive epithelial sodium channel, ENaC, is a heteromultimeric protein
made up of three homologous subunits (α, β and γ) 1, 2. In vitro, assembly and expression of
functional active sodium channels in the Xenopus oocyte is strictly dependent on αENaC—
the β and γ sub-units by themselves are unable to induce an amiloride-sensitive sodium
current in this heterologous expression system2. In vivo, ENaC constitutes the limiting step
for sodium absorption in epithelial cells that line the distal renal tubule, distal colon and the …
made up of three homologous subunits (α, β and γ) 1, 2. In vitro, assembly and expression of
functional active sodium channels in the Xenopus oocyte is strictly dependent on αENaC—
the β and γ sub-units by themselves are unable to induce an amiloride-sensitive sodium
current in this heterologous expression system2. In vivo, ENaC constitutes the limiting step
for sodium absorption in epithelial cells that line the distal renal tubule, distal colon and the …