Transforming growth factor-β regulates tubular epithelial-myofibroblast transdifferentiation in vitro
JM Fan, YY Ng, PA Hill, DJ Nikolic-Paterson, W Mu… - Kidney international, 1999 - Elsevier
Transforming growth factor-β regulates tubular epithelial-myofibroblast transdifferentiation in
vitro. Background We recently found evidence of tubular epithelial-myofibroblast
transdifferentiation (TEMT) during the development of tubulointerstitial fibrosis in the rat
remnant kidney. This study investigated the mechanisms that induce TEMT in vitro. Methods
The normal rat kidney tubular epithelial cell line (NRK52E) was cultured for six days on
plastic or collagen type I-coated plates in the presence or absence of recombinant …
vitro. Background We recently found evidence of tubular epithelial-myofibroblast
transdifferentiation (TEMT) during the development of tubulointerstitial fibrosis in the rat
remnant kidney. This study investigated the mechanisms that induce TEMT in vitro. Methods
The normal rat kidney tubular epithelial cell line (NRK52E) was cultured for six days on
plastic or collagen type I-coated plates in the presence or absence of recombinant …