Insulin and leptin are hypothesized to beadiposity signals' for the long-term regulation of
body weight by the brain. Accordingly, a change in the plasma levels of leptin or insulin
indicates a state of altered energy homeostasis and adiposity, and the brain responds by
adjusting food intake to restore adipose tissue mass to a regulated level. The candidate site
for the brain's detection of leptin adiposity signaling is the hypothalamic arcuate nucleus,
where leptin inhibits expression neuropeptide Y and increases expression of the pro …