Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and …
J Spranger, A Kroke, M Mohlig, K Hoffmann… - Diabetes, 2003 - Am Diabetes Assoc
A subclinical inflammatory reaction has been shown to precede the onset of type 2 (non-
insulin-dependent) diabetes. We therefore examined prospectively the effects of the central
inflammatory cytokines interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) on the
development of type 2 diabetes. We designed a nested case-control study within the
prospective population-based European Prospective Investigation into Cancer and Nutrition
(EPIC)-Potsdam study including 27,548 individuals. Case subjects were defined to be those …
insulin-dependent) diabetes. We therefore examined prospectively the effects of the central
inflammatory cytokines interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) on the
development of type 2 diabetes. We designed a nested case-control study within the
prospective population-based European Prospective Investigation into Cancer and Nutrition
(EPIC)-Potsdam study including 27,548 individuals. Case subjects were defined to be those …